Dinalin
Dinalin Basic information
- Product Name:
- Dinalin
- Synonyms:
-
- Dinalin
- dinaline
- GOE1734
- PD-104208
- Benzamide, 4-amino-N-(2-aminophenyl)-
- Dinaline, Antineoplastic agent
- CAS:
- 58338-59-3
- MF:
- C13H13N3O
- MW:
- 227.26
- Mol File:
- 58338-59-3.mol
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Dinalin Chemical Properties
- Melting point:
- 180.5°C
- Boiling point:
- 368.98°C (rough estimate)
- Density
- 1.1267 (rough estimate)
- refractive index
- 1.5600 (estimate)
- storage temp.
- Store at Room Tem.
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Dinalin Usage And Synthesis
Uses
Dinaline (GOE 1734; PD 104 208; NSC 328786) is a potent and orally activity anticancer agent. Dinaline shows cytotoxicity and antitumor activity. Dinaline has the potential for the research of colorectal cancer[1].
in vivo
Dinaline (5.9, 7.7, 10 mg/kg; p.o.; 5 days per week for 10 weeks) inhibits tumor growth in rats[1].
| Animal Model: | 140-160 g, male Sprague-Dawley rats[1] |
| Dosage: | 5.9, 7.7, 10 mg/kg |
| Administration: | P.o.; 5 days per week for 10 weeks |
| Result: | Showed significant tumor growth inhibition in a dose-dependent manner with the ratio of median tumor volume of (T/C%) values of 0.4, 16 and 10.6 at 10, 7.7 and 5.9 mg/kg respectively. |
References
[1] Seelig MH, et al. Efficacy of dinaline and its methyl and acetyl derivatives against colorectal cancer in vivo and in vitro. Eur J Cancer. 1996 Oct;32A(11):1968-76. DOI:10.1016/0959-8049(96)00217-1
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