Yuanhuacine
Yuanhuacine Basic information
- Product Name:
- Yuanhuacine
- Synonyms:
-
- Yuanhuacine
- gnidilatidin
- (22E,24E)-12β-Benzoyloxy-22,23,24,25-tetradehydrosimplexin
- Odoracin
- From gnidia
- Gnidia B644130K130 origin
- Nsc261422
- NSC 270919
- CAS:
- 60195-70-2
- MF:
- C37H44O10
- MW:
- 648.74
- Mol File:
- 60195-70-2.mol
Yuanhuacine Chemical Properties
- Boiling point:
- 765.9±60.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- pka
- 11.00±0.70(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- CGSGRJNIABXQJQ-NSCQCFIPSA-N
- SMILES
- O1[C@@]2(C(C)=C)[C@H](OC(=O)C3=CC=CC=C3)[C@@H](C)[C@@]34O[C@]1(/C=C/C=C/CCCCC)O[C@]2([H])[C@]3([H])[C@]1([H])O[C@]1(CO)[C@@H](O)[C@@]1(O)[C@@]4([H])C=C(C)C1=O
Yuanhuacine Usage And Synthesis
Uses
Yuanhuacine (Gnidilatidin), a diterpene from Daphne genkwa, is an effective and highly selective inhibitor of the basal-like 2 (BL2) subtype of TNBC. Yuanhuacine can induce G2/M cell cycle arrest and has broad anti-tumor activity. Yuanhuacine is an orally active DNA damaging agent[1][2][3].
in vivo
Yuanhuacine (0.5-1 mg/kg, oral, once daily, 21 days) inhibits tumor proliferation in mice[1].
| Animal Model: | H1993 cells implanted xenograft mouse model[1] |
| Dosage: | 0.5, 1 mg/kg; daily; 21 days |
| Administration: | Oral |
| Result: | Inhibited tumor growth by 33.4% and 38.8%, respectively, reduced tumor weight, activated AMPK, and inhibited proliferation biomarkers Ki-67 and PCNA in tumor tissues. |
References
[1] Ji In Kang, et al. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368. DOI:10.1371/journal.pone.0144368
[2] Ruowen Zhang, et al. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403. DOI:10.1074/jbc.M113.513960
[3] Charles S Fermaintt, et al. Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential. Cancers (Basel). 2021 Jun 7;13(11):2834. DOI:10.3390/cancers13112834
YuanhuacineSupplier
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- 17308096051
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- +86-028-82633397 18982077548
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- Tel
- 021-51320588
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- 021-61312847; 18021002903
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- 021-68882955 17721395025
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