4-Chlorovalerophenone Chemical Properties

Melting point:

29-33 °C

Boiling point:

156 °C / 14mmHg

Density 

1.0753 (rough estimate)

refractive index 

1.5364 (estimate)

Flash point:

30 °C

storage temp. 

Sealed in dry,Room Temperature

form 

fused solid

color 

Off-white to faint yellow

InChI

InChI=1S/C11H13ClO/c1-2-3-4-11(13)9-5-7-10(12)8-6-9/h5-8H,2-4H2,1H3

InChIKey

XMUGWCSIQUJOFA-UHFFFAOYSA-N

SMILES

C(C1=CC=C(Cl)C=C1)(=O)CCCC

CAS DataBase Reference

25017-08-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26-24/25

RIDADR 

3077

HS Code 

29420000

MSDS

• Language:English Provider:1-(4-Chlorophenyl)-1-pentanone
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Chlorovalerophenone Usage And Synthesis

Chemical Properties

white to yellow crystalline low melting solid

Uses

4-Chlorovalerophenone is often used as a pharmaceutical intermediate.

Synthesis

A mixture of 346 ml of chlorobenzene and 120 g of valeryl chloride is treated, at room temperature, in the course of 1 hour with portions of aluminium chloride and the mixture is at the same time heated to 70°. The mixture is stirred for a further hour at this temperature and then cooled to 25° and the dark red reaction mixture is poured on to 1,000 g of ice. Concentrated hydrochloric acid is added and the mixture is then extracted with ethyl acetate. The organic extract is washed with 2 N hydrochloric acid, filtered through a diatomaceous earth formulation (Hyflo) and washed with further 2 N hydrochloric acid, twice with water, with a 2 N aqueous solution of sodium carbonate and with water. It is dried over sodium sulphate and filtered and the filtrate is evaporated under reduced pressure. The residue is distilled; 4-Chlorovalerophenone is obtained at 155°-156°/14 mm Hg; the product crystallises and melts at 28°-30°.

4-Chlorovalerophenone (25017-08-7)Related Product Information

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