[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Chemical Properties

Density 

1.48±0.1 g/cm3(Predicted)

pka

9.82±0.15(Predicted)

form 

Solid

color 

White to off-white

Sequence

{Pyr}-His-Trp-Ser-Tyr-{d-Ala}-Leu-Arg-Pro-NHEt

[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate Usage And Synthesis

Chemical Properties

Off-white freeze-dried powder. Soluble in water and saline.

Uses

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility[1][2][3].

in vivo

References

[1] Wan B, et al. Polymer source affects in vitro-in vivo correlation of leuprolide acetate PLGA microspheres. Int J Pharm. 2022 Sep 25;625:122032. DOI:10.1016/j.ijpharm.2022.122032
[2] Masalova OO, et al. Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats. Bull Exp Biol Med. 2019 Nov;168(1):52-54. DOI:10.1007/s10517-019-04644-4
[3] Kraevskiy A Y, et al. Surfagon and Ketaprofen for increasing fertility and preventing embryonic death in cows after insemination AY[J]. Ukrainian Journal of Ecology, 2020, 10(4): 159-164.