4-Nitrophenylhydrazine Chemical Properties

Melting point:

156 °C (dec.)(lit.)

Boiling point:

276.04°C (rough estimate)

Density 

1.00

refractive index 

1.6910 (estimate)

storage temp. 

Explosives area

pka

3.81±0.20(Predicted)

color 

Orange-red leaflets or needles

Water Solubility 

soluble in hot water

Merck 

14,6624

BRN 

608107

CAS DataBase Reference

100-16-3(CAS DataBase Reference)

NIST Chemistry Reference

P-nitrophenyl hydrazine(100-16-3)

EPA Substance Registry System

Hydrazine, (4-nitrophenyl)- (100-16-3)

Safety Information

Hazard Codes 

F,Xn

Risk Statements 

5-11-22-36/37/38-43-21/22

Safety Statements 

16-26-36/37/39-37/39-36

RIDADR 

UN 3376 4.1/PG 1

WGK Germany 

3

RTECS 

MV8225000

F 

4.6

Hazard Note 

Flammable/Harmful

HazardClass 

4.1

PackingGroup 

I

HS Code 

29280000

Toxicity

mmo-sat 2 mmol/L AEMIDF 44,801,82

MSDS

• Language:English Provider:4-Nitrophenylhydrazine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
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4-Nitrophenylhydrazine Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

Analytical reagent (aldehydes, ketones).

Uses

4-Nitrophenylhydrazine is a nitro substituted aryl hydrazine with potential anticancer activity. Irritant.

Definition

ChEBI: A member of the class of phenylhydrazines that is phenylhydrazine substituted at the 4-position by a nitro group.

General Description

4-Nitrophenylhydrazine is a orange-red leaflet or needles wetted with water. 4-Nitrophenylhydrazine will emit toxic oxides of nitrogen when heated to decomposition. 4-Nitrophenylhydrazine is slightly heavier than water and insoluble in water. 4-Nitrophenylhydrazine may be irritating to skin, eyes and mucous membranes. 4-Nitrophenylhydrazine may be toxic by ingestion. 4-Nitrophenylhydrazine may be explosive and sensitive to friction in the dry state. 4-Nitrophenylhydrazine is used as a reagent for ketones and aliphatic aldehydes.

Reactivity Profile

4-NITROPHENYLHYDRAZINE is a powerful explosive. 4-Nitrophenylhydrazine can SELF-IGNITE in the presence of contaminants. Auto-ignition temperature may vary for 4-nitrophenylhydrazine similar to that of hydrazine which has an autoignition of as low as 74oC in contact with iron rust. Dangerous fire hazard or severe explosion can occur when exposed to heat, flame or oxidizing agents. Severe explosion may also occur by chemical reaction with alkali metals; BaO; CaO; K; Na; NH3; Cl2; chromates; CuO; Cu++ salts; F2; H2O2; iron rust; metallic oxides; PbO2;Ni; Ni(ClO4)2; HNO3; N2O; O2; liquid O2; K2Cr2O7; Na2Cr2O7; tetryl; zinc diamide; Zn(C2H5)2. Dangerous; when heated to decomposition 4-Nitrophenylhydrazine emits highly toxic nitrogen compounds; may explode by heat or chemical reaction. (Sax and Lewis, 1987) under Hydrazine p. 538-539.

Health Hazard

Some are toxic and may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution.

Safety Profile

Poison by intraperitoneal route.Mutation data reported. When heated to decomposition itemits toxic fumes of NOx. See also NITROCOMPOUNDS OF AROMATIC HYDROCARBONS

Purification Methods

Crystallise the hydrazine from EtOH. The hydrochloride has m 212o(dec) (from EtOH, also m 202-203o dec). [Beilstein 15 III 331, 15 IV 317.]

4-Nitrophenylhydrazine(100-16-3)Related Product Information

• p-Nitrophenylacetonitrile
• 4-Nitrophenyl chloroformate
• Sodium 3-nitrobenzenesulphonate
• 4-Nitrobenzaldehyde
• 4-Nitrophenylacetic acid
• 4-NITROPHENYLACETYLENE
• 4-Fluoronitrobenzene
• 4-Nitrobenzonitrile
• 3-Nitrobenzaldehyde
• 4-Nitrobenzeneethanol
• 3,4-Difluoronitrobenzene
• 4-Nitrobenzoic acid
• 3-Nitrophenylhydrazine hydrochloride
• Nitrobenzene
• 2,2-DI(4-TERT-OCTYLPHENYL)-1-PICRYL-HYDRAZYL, FREE RADICAL
• 2,2-diphenyl-1-picrylhydrazyl
• 4-Nitrophenylhydrazine
• 1,3-Dinitrobenzene