(S,S)-Formoterol Chemical Properties

Boiling point:

603.2±55.0 °C(Predicted)

Density 

1.233±0.06 g/cm3(Predicted)

pka

8.95±0.50(Predicted)

(S,S)-Formoterol Usage And Synthesis

Uses

(S,S)-Formoterol ((+)-Formoterol) is a (S,S)-enantiomer of Formoterol. (S,S)-Formoterol can promote asthma by enhancing IL-4 production in mast cells of the asthmatic airway[1].

Definition

ChEBI: (S,S)-formoterol is an N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide in which both of the stereocentres have S configuration. It is a conjugate base of a (S,S)-formoterol(1+). It is an enantiomer of an arformoterol.

References

[1] Abraha D, et, al. (S,S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model. Int Arch Allergy Immunol. 2004 Apr;133(4):380-8. DOI:10.1159/000077358
[2] Jensen O, et, al. Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters. Biochem Pharmacol. 2020 Jan;171:113731. DOI:10.1016/j.bcp.2019.113731

(S,S)-Formoterol(67346-48-9)Related Product Information

• N,O-Dibenzylated formoterol
• 4-methoxyamphetamine hydrochloride
• Formamide, N-[2-(4-methoxyphenyl)-1-methylethyl]-
• Formoterol EP Impurity F
• 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone
• Formoterol EP Impurity E
• Arformoterol Impurity 24
• Formoterol O-β-D-Glucuronide
• (R,R)-Formoterol
• Formoterol fumarate
• FORMOTEROL-D3
• Formoterol Fumarate Dihydrate EP Impurity I
• Formoterol EP Impurity C
• 1-(4-Methoxyphenyl)-2-benzylaminopropane
• (R)-2-(4-Methoxyphenyl)-1-methylethanamine
• Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, [R-(R*,S*)]-
• Formoterol Impurity 13
• Formoterol EP Impurity D