3-(4-Chlorophenyl)glutaramic acid Chemical Properties

Melting point:

168-170°C

Boiling point:

494.9±40.0 °C(Predicted)

Density 

1.343±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Methanol (Slightly)

form 

Solid

pka

4.50±0.10(Predicted)

color 

White

BRN 

2460842

CAS DataBase Reference

1141-23-7(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36

MSDS

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3-(4-Chlorophenyl)glutaramic acid Usage And Synthesis

Uses

3-(4-Chlorophenyl)glutaramic acids serves as a reagent for the synthesis of heterocyclic compounds as mGlu5 antagonists for treating urinary tract disorders, migraine, and gastroesophageal reflux disease.

Synthesis

General procedure for the synthesis of 3-(4-chlorophenyl)glutaric acid monoamide from 3-(4-chlorophenyl)glutaric acid monoamide: Intermediate IV (120 g, 0.537 mol) was taken, aqueous sodium hydroxide solution (600 μl, 15N) was added, and the reaction was stirred for 1.5 hr at 65-70 °C. After the reaction was completed, it was cooled to room temperature and toluene (500 ml) and deionized water (700 ml) were added. The mixture was stirred for 20 min, and the organic layer was discarded after standing and layering. The pH of the aqueous layer was adjusted to 2~3 with concentrated hydrochloric acid, left to stand and filtered, and the solids were washed with water. The solid was dried under vacuum at 55~60°C for 5 hours to give 116 g of white solid intermediate V in 89.5% yield.

References

[1] Patent: CN106187794, 2016, A. Location in patent: Paragraph 0025; 0030

3-(4-Chlorophenyl)glutaramic acid(1141-23-7)Related Product Information

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• ETHYL 4-(4-CHLOROPHENYL)-1-(2-ETHOXY-2-OXOETHYL)-2-METHYL-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLATE
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• 3-(4-Chlorophenyl)glutaramic acid
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