N-ACETYL-L-CYSTEINE METHYL ESTER Chemical Properties

Melting point:

77-81 °C

Boiling point:

584.5±50.0 °C(Predicted)

Density 

1.285±0.06 g/cm3(Predicted)

storage temp. 

-15°C

solubility 

DMSO: Soluble: = 10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml

pka

13.89±0.46(Predicted)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

10-23

MSDS

• Language:English Provider:SigmaAldrich

N-ACETYL-L-CYSTEINE METHYL ESTER Usage And Synthesis

Description

Dimethyl diacetyl cystinate is a derivative of the oxidized dimeric form of cysteine L-cystine (Item No. 31727).1 It inhibits UVB radiation-induced NF-κB nuclear translocation in and IL-1α secretion from HaCaT cells when used at concentrations of 50 or 100 µM. Dimethyl diacetyl cystinate (10 µg/ml) decreases proliferation and IFN-γ and IL-2 secretion in a co-culture of lymphocytes isolated from BALB/c mice and irradiated splenocytes isolated from C57BL/10J mice.2 Subconjunctival administration of dimethyl diacetyl cystinate (8 µg/animal) reduces corneal glutathione (GSH) levels and increases corneal allograft survival in mice.WARNING This product is not for human or veterinary use.

Chemical Properties

White powder

References

[1] MANABU KITAZAWA. Intracellular redox regulation by a cystine derivative suppresses UV-induced NF-κB activation[J]. FEBS Letters, 2002, 526 1-3: 106-110. DOI: 10.1016/s0014-5793(02)03152-6
[2] JUN YAMADA. Major histocompatibility complex semi-matching improves murine corneal allograft survival under oxidative macrophage dominancy.[J]. Transplantation, 2007, 84 7: 899-907. DOI: 10.1097/01.tp.0000284731.22247.a3

N-ACETYL-L-CYSTEINE METHYL ESTER(32381-28-5)Related Product Information

• AC-CYS(FARNESYL)-OME
• N-ACETYL-L-CYSTEINE METHYL ESTER
• (DES-GLY)-GLUTATHIONE-MONOETHYL ESTER (REDUCED)
• N-(3-nitratopivaloyl)cysteine ethyl ester
• N-ACETYL-S-BENZYL-L-CYSTEINE METHYL ESTER
• ALANINE, N-ACETYL-3-((2-CHLORO-2-METHYLPROPYL)THIO)-, METHYL ESTER, L-
• N-TRIFLUOROACETYL-L-CYSTEINE METHYL ESTER
• N,N'-BIS(TRIFLUOROACETYL) L-CYSTINE DIMETHYL ESTER
• N,S-DIACETYL-L-CYSTEINE METHYL ESTER
• N-ACETYL-L-CYSTEINE METHYL ESTER
• BOC-CYSTINE-ALA-ALA-GLY-VAL-CYSTEINE-OME
• BOC-CYSTINE-PHE-CYSTEINE-OME
• FA-CYS(FARNESYL)-OME
• CBZ-GLY-S-BENZYL-L-CYS-S-BENZYL-L-CYS ETHYL ESTER
• BOC-CYSTINE-CYSTEINE-OME
• AC-CYS-HIS-SER-GLY-TYR-VAL-GLY-VAL-ARG-CYS-OME
• N-TRIFLUOROACETYL-L-G-GLUTAMYL-L-CYSTEINE DIMETHYL ESTER, (2-2') DISULPHIDE
• BOC-CYSTINE-GLY-GLY-GLY-GLY-CYSTEINE-OME