2,3,5-Trifluoropyridine Chemical Properties

Boiling point:

102°C

Density 

1,499 g/cm³

refractive index 

1.422

Flash point:

30°C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

clear liquid

pka

-5.28±0.20(Predicted)

color 

Colorless to Light yellow

Specific Gravity

1.499

Water Solubility 

Difficult to mix in water.

BRN 

6385503

CAS DataBase Reference

76469-41-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,F,C

Risk Statements 

36/37/38-10

Safety Statements 

26-36/37/39-37

RIDADR 

1993

Hazard Note 

Flammable/Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

29333990

MSDS

• Language:English Provider:2,3,5-Trifluoropyridine
• Language:English Provider:ALFA

2,3,5-Trifluoropyridine Usage And Synthesis

Synthesis

A solution of pentafluoropyridine (3) (0.6 g, 3.6 mmol) in tetrahydrofuran (5  cm3) was added to a mixture of lithium aluminium hydride (5 cm3, 5 mmol of 1.0 M  solution in ether) and 12-crown-4 (1.0 g, 5.7 mmol) in THF (10 cm3) at 0 "C, with  stirring, under an atmosphere of dry nitrogen. The mixture was stirred at 0 "C for 10  min, then at room temperature for 19 h, then iced water added and the mixture extracted  into ether. The ether solution was dried (MgS04), evaporated and the products were  isolated by preparative scale GLC (1 0% SE, 40"C), giving 2,3,5-trifluoropyridine (7,  92%) 50(Found: C, 44.9; H, 1.3; N, 10.5. Calc. for C5H2F3N: C, 45.1; H, 1.5; N,  10.5); IR spectrum no. 2; mass spectrum no. 3; nmr spectrum no. 3.

Chemical Properties

Colorless liquid

Uses

It is employed as a pharmaceutical intermediate.

2,3,5-Trifluoropyridine(76469-41-5)Related Product Information

• 3-Aminopyridine
• 2,4,6-Collidine
• 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
• Pyridine sulfur trioxide
• 2,3,5,6-Tetrafluoropyridine
• 2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE
• 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE
• 4-(DIMETHYLAMINO)-2,3,5,6-TETRAFLUOROPYRIDINE
• 2 3 5 6-TETRAFLUORO-4-METHYLPYRIDINE 9&
• Pentafluoropyridine
• 2,3,5-TRIFLUOROPYRIDINE-4-CARBOXYLIC ACID
• 2,4,5-Trifluoropyridine
• 2-Amino-3-chloro-5-trifluoropyridine
• 2,4,6-Trifluoropyridine 98%,2,4,6-Trifluoropyridine98%,2,4,6-TRIFLUOROPYRIDINE
• 2,3,4-Trifluoropyridine
• 3,5-Dichloro-2,4,6-trifluoropyridine
• 2,3,6-TRIFLUOROPYRIDINE-4-CARBOXYLIC ACID
• 2,3,5-TRIFLUOROPYRIDINE-4-CARBOXYLIC ACID, 97,2,3,5-TRIFLUOROPYRIDINE-4-CARBOXYLIC AC&