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2,3,5-Trifluoropyridine

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2,3,5-Trifluoropyridine Basic information

Product Name:
2,3,5-Trifluoropyridine
Synonyms:
  • 2,3,5-TRIFLUOROPYRIDINE
  • 2,3,5-Trifluoropyridine 98%
  • 2,3,5-Trifluoropyridine98%
  • Pyridine, 2,3,5-trifluoro-
  • 2,3,5-Trifluoropyridine ISO 9001:2015 REACH
CAS:
76469-41-5
MF:
C5H2F3N
MW:
133.07
EINECS:
680-886-9
Product Categories:
  • Fluorine series
  • Pyridine
  • bc0001
Mol File:
76469-41-5.mol
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2,3,5-Trifluoropyridine Chemical Properties

Boiling point:
102°C
Density 
1,499 g/cm3
refractive index 
1.422
Flash point:
30°C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-5.28±0.20(Predicted)
form 
clear liquid
Specific Gravity
1.499
color 
Colorless to Light yellow
Water Solubility 
Difficult to mix in water.
BRN 
6385503
CAS DataBase Reference
76469-41-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,F,C
Risk Statements 
36/37/38-10
Safety Statements 
26-36/37/39-37
RIDADR 
1993
Hazard Note 
Flammable/Irritant
HazardClass 
3
PackingGroup 
III
HS Code 
29333990

MSDS

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2,3,5-Trifluoropyridine Usage And Synthesis

Synthesis

A solution of pentafluoropyridine (3) (0.6 g, 3.6 mmol) in tetrahydrofuran (5  cm3) was added to a mixture of lithium aluminium hydride (5 cm3, 5 mmol of 1.0 M  solution in ether) and 12-crown-4 (1.0 g, 5.7 mmol) in THF (10 cm3) at 0 "C, with  stirring, under an atmosphere of dry nitrogen. The mixture was stirred at 0 "C for 10  min, then at room temperature for 19 h, then iced water added and the mixture extracted  into ether. The ether solution was dried (MgS04), evaporated and the products were  isolated by preparative scale GLC (1 0% SE, 40"C), giving 2,3,5-trifluoropyridine (7,  92%) 50(Found: C, 44.9; H, 1.3; N, 10.5. Calc. for C5H2F3N: C, 45.1; H, 1.5; N,  10.5); IR spectrum no. 2; mass spectrum no. 3; nmr spectrum no. 3.

Chemical Properties

Colorless liquid

Uses

It is employed as a pharmaceutical intermediate.

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