Basic information Safety Supplier Related

Midostaurin

Basic information Safety Supplier Related

Midostaurin Basic information

Product Name:
Midostaurin
Synonyms:
  • CGP 41251MIDOSTAURIN(PKC412)
  • N-((5S,6R,7R,9R)-6-Methoxy-14-oxo-5,6,7,8,9,14,15,16-octahydro-17-oxa-4b,9a,15-triaza-5,9-Methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-MethylbenzaMide
  • PKC-412, CGP-41251
  • Midostaurin (PKC412)
  • PKC412 (Midostaurin)
  • CGP 41231
  • N-Benzoylstaurosporine
  • (Midostaurin) Benzoylstaurosporine
CAS:
120685-11-2
MF:
C35H30N4O4
MW:
570.64
EINECS:
999-999-2
Product Categories:
  • antibiotic
  • Pharmaceutical
Mol File:
120685-11-2.mol
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Midostaurin Chemical Properties

Melting point:
235-260℃
Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml), 100% ethanol (2.5 mg/ml), and DMF (20 mg/ml).
form 
Tan solid
pka
14.19±0.70(Predicted)
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Safety Information

Hazard Codes 
T
Risk Statements 
36/37/38
HS Code 
29329990
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Midostaurin Usage And Synthesis

Uses

Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.

Uses

Midostaurin is used as a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Due to this act which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors. Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.

Definition

ChEBI: An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.

Biological Activity

Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms ( α , β , γ ), PDFR β , VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

MidostaurinSupplier

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