(D-ARG0,HYP3,D-PHE7)-BRADYKININ Chemical Properties

storage temp. 

−20°C

Sequence

{d-Arg}-Arg-Pro-{Hyp}-Gly-Phe-Ser-{d-Phe}-Phe-Arg

Safety Information

WGK Germany 

3

MSDS

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(D-ARG0,HYP3,D-PHE7)-BRADYKININ Usage And Synthesis

Uses

NPC-567 is a bradykinin B2 receptor antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways[1][2].

Definition

ChEBI: A ten-membered oligopeptide comprising D-arginyl, L-arginyl, L-prolyl, (4R)-4-hydroxy-L-prolyl, glycyl, L-phenylalanyl, L-seryl, -phenylalanyl, L-phenylalanyl and L-arginine residues joined in sequence.

References

[1] Cheronis JC, et al. A new class of bradykinin antagonists: synthesis and in vitro activity of bissuccinimidoalkane peptide dimers. J Med Chem. 1992 May 1;35(9):1563-72. DOI:10.1021/jm00087a010
[2] Sylvin H, et al. The effect of a bradykinin B2 receptor antagonist, NPC-567, on allergen-induced airway responses in a porcine model. Inflamm Res. 2001 Sep;50(9):453-9. DOI:10.1007/PL00000270

(D-ARG0,HYP3,D-PHE7)-BRADYKININ(109333-26-8)Related Product Information

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