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desmethylazelastine

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desmethylazelastine Basic information

Product Name:
desmethylazelastine
Synonyms:
  • 4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1H-azepin-4-yl)-1(2H)-phthalazinone
  • Demethylazelastine
  • N-Desmethyl Azelastine
  • Azelastine Hydrochloride Impurity
  • 4-(p-Chlorobenzyl)-2-[(hexahydro-1H-azepin)-4-yl]phthalazin-1(2H)-one
  • Azelastin IMP
  • N-Desmethyl Azelastine (1.0mg/ml in DMSO)
  • Azelastine Impurity 6
CAS:
47491-38-3
MF:
C21H22ClN3O
MW:
367.87
Product Categories:
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
Mol File:
47491-38-3.mol
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desmethylazelastine Chemical Properties

Melting point:
90-95°C
Boiling point:
544.1±60.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
10.49±0.40(Predicted)
color 
Pale Yellow to Light Yellow
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desmethylazelastine Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

The main phase I metabolites of Azelastine.

in vivo

1.19Pharmacokinetic parameters of desmethylazelastine after a single oral administration of 1.0 mg/kg azelastine hydrochloride in guinea pigs[1].
BloodLung
Cmax (ng/mL)[a]17.62863
Tmax (h)3.0-6.04.0-6.0
Tlag (h)0.250.39
AUC0-24 (ng?h/mL)[a]18028502
t1/2 (h)4.243.90
CL (L/h)0.213
Lung-blood ratio[b]146146
[a] For lung, the unit in grams (g) instead of milliliter (mL). [b] Mean value calculated from all time points.

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