gelucire 44-14
gelucire 44-14 Basic information
- Product Name:
- gelucire 44-14
- Synonyms:
-
- gelucire 44-14
- Gelucire 14/44
- GELUCIRE 50/02 AND GELUCIRE 50/13
- gelucire 44-14 ISO 9001：2015 REACH
- Lauroyl Polyoxylglycerides 1500 (500 mg)
- CAS:
- 121548-04-7
- MW:
- 0
- Mol File:
- Mol File
gelucire 44-14 Chemical Properties
- form
- Oil
- color
- Off-white to light yellow
gelucire 44-14 Usage And Synthesis
Uses
Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable agents including insulin and calcitonin by pulmonary delivery.
in vivo
Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable drugs including insulin and calcitonin by pulmonary delivery. It is found that pulmonary absorptions of FD4, FD10 and FD70 are enhanced in different degree by Gelucire 44/14 in a concentration-dependent manner, and the maximal absorption-enhancing effect is obtained when the concentration of Gelucire 44/14 reaches to 2.0% (w/v). It is also found that the absorption enhancing ability of Gelucire Gelucire 44/14 is correlated with the molecular weight of model drugs, and the highest absorption enhancement ratio of Gelucire Gelucire 14/44 is observed when the molecular weight of model drugs reaches to nearly 10000 Da[1].
References
[1] Zhang H, et al. Improvement of pulmonary absorptions of poorly absorbable drugs using Gelucire 44/14 as an absorption enhancer. J Pharm Pharmacol. 2014 Oct;66(10):1410-20. DOI:10.1111/jphp.12274
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