Norfenfluramine Chemical Properties

Boiling point:

96 °C(Press: 17 Torr)

Density 

1.152±0.06 g/cm3(Predicted)

pka

9.77±0.10(Predicted)

Safety Information

Toxicity

LD50 intraperitoneal in mouse: 51mg/kg

Norfenfluramine Usage And Synthesis

Uses

Norfenfluramine ((±)-Norfenfluramine) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine displays antiepileptic effects in vivo[1][2].

Definition

ChEBI: 1-[3-(trifluoromethyl)phenyl]-2-propanamine is a member of amphetamines.

References

[1] Rothman RB, et, al. (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003 Jun;305(3):1191-9. DOI:10.1124/jpet.103.049684
[2] Li J, et, al. Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochem Res. 2021 Sep;46(9):2249-2261. DOI:10.1007/s11064-021-03358-2

Norfenfluramine(1886-26-6)Related Product Information

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