mebikar
mebikar Basic information
- Product Name:
- mebikar
- Synonyms:
-
- mebikar
- 2,4,6,8-Tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]-3,7-oxandione
- 3a,4,6,6a-Tetrahydro-1,3,4,6-tetramethylimidazo[4,5-d]imidazole-2,5(1H,3H)-dione
- 4,5-(1,3-Dimethylureylene)-1,3-dimethylimidazolidine-2-one
- Mebicar
- 1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-dione
- 1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-quinone
- 1,3,4,6-Tetramethyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione
- CAS:
- 10095-06-4
- MF:
- C8H14N4O2
- MW:
- 198.22
- Mol File:
- 10095-06-4.mol
mebikar Chemical Properties
- Melting point:
- 226 - 229?C
- Boiling point:
- 362.2±42.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator, under inert atmosphere
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -0.49±0.20(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C8H14N4O2/c1-9-5-6(11(3)7(9)13)12(4)8(14)10(5)2/h5-6H,1-4H3
- InChIKey
- XIUUSFJTJXFNGH-UHFFFAOYSA-N
- SMILES
- CN1C(N(C2N(C(N(C21)C)=O)C)C)=O
mebikar Usage And Synthesis
Uses
Temgicoluril (Tetramethylglycoluril) is an orally active antianxiety and antidepressant. Temgicoluril acts on GABA receptors to enhance GABA neurotransmission[1][2].
Definition
ChEBI: Mebicar is an imidazolidinone.
in vivo
Temgicoluril (10 mg/kg; Oral gavage; 3 weeks) has a preventive effect on neurobehavioral and immunological disruptions caused by intermittent unpredictable stress in mice[2].
| Animal Model: | Intermittent unpredictable stress (IUS) treated seven week-old Balb/cByJ mice[2] |
| Dosage: | 10 mg/kg |
| Administration: | Oral gavage (i.g.); 3 weeks |
| Result: | Recovered rapidly from anxiety-like behavior induced by the multiplexed stress compared with untreated mice. Did not prevent the decrease of brain-derived neurotropic factor by IUS exposure. Prevented elevation of serum corticosterone and secretion of proinflammatory cytokines from splenocytes due to IUS exposure. |
References
[1] Val'dman AV, Zaikonnikova IV, Kozlovskaia MM, Zimakova IE. Izuchenie osobennoste? spektra psikhotropnogo de?stviia mebikara [Characteristics of the psychotropic spectrum of action of mebicar]. Biull Eksp Biol Med. 1980 May;89(5):568-70. Russian. PMID:6104993
[2] Kim CY, et al. Preventive Effect of Mebicar and Ginsenoside Rg1 on Neurobehavioral and Immunological Disruptions Caused by Intermittent Unpredictable Stress in Mice. Neuroimmunomodulation. 2018;25(1):49-58. DOI:10.1159/000489634
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