alpha-Methyldopa sesquihydrate Chemical Properties

Melting point:

>300 °C(lit.)

storage temp. 

2-8°C

solubility 

Slightly soluble in water, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute mineral acids.

color 

White to Off-White

optical activity

[α]25/D 13°, c = 1 in H2O

Water Solubility 

0.1-1 g/100 mL at 23 ºC

Sensitive 

Air & Light Sensitive

Merck 

13,6080

BRN 

2417244

Stability:

Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere.

CAS DataBase Reference

41372-08-1(CAS DataBase Reference)

Safety Information

Risk Statements 

20/21-36/37/38-42/43-65

Safety Statements 

24/25

WGK Germany 

3

RTECS 

YP2860000

F 

10-23

HS Code 

2922504500

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

alpha-Methyldopa sesquihydrate Usage And Synthesis

Chemical Properties

White Solid

Uses

Potent inhibitor of invertase and glucosidase inhibitor with a different specificity of action to DNJ and castanospermine. Inhibits glucosidase I.

Uses

Antihypertensive agent.

Biological Activity

l-(-)-α-methyldopa (hydrate) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.

Purification Methods

Recrystallise methyldopa from H2O. [Reinhold et al. J Org Chem 33 1209 1968.] The L-isomer forms a sesquihydrate from H2O m 302-304o (dec), and the anhydrous crystals are hygroscopic,[] 23D -4.0o (c 1, 0.1N HCl), []546 +154.5o (c 5, CuSO4 solution). It has max at 281nm ( 2780). Its solubility in H2O at 25o is ~10mg/mL and the pH of an aqueous solution is ~5.0. It is insoluble in most organic solvents. [Stein et al. J Am Chem Soc 77 700 1955, Beilstein 4 IV 2505.]

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