6-Methoxy-2-naphthaldehyde Chemical Properties

Melting point:

81-84 °C(lit.)

Boiling point:

196 °C / 10mmHg

Density 

1.169±0.06 g/cm3(Predicted)

vapor pressure 

0.022Pa at 25℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly, Sonicated)

form 

powder to crystal

color 

White to Light yellow to Light orange

Water Solubility 

150.1mg/L at 25℃

Sensitive 

Air Sensitive

BRN 

1945989

LogP

2.97 at 25℃

CAS DataBase Reference

3453-33-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29124990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

6-Methoxy-2-naphthaldehyde Usage And Synthesis

Chemical Properties

yellow to beige-yellow crystals or crystalline

Uses

6-Methoxy-2-naphthaldehyde is used as a diagnostic reagent in tumor studies involving aldehyde dehydrogenase enzymes. In addition it is used in organic synthesis reactions forming fluorescent substrates for inhibition studies relating to hypertension and vascular inflammation. It is also used as intermediate of Nabumetone.

Uses

6-Methoxy-2-naphthaldehyde may be used in the preparation of the following 4-(6-methoxy-2-naphthyl)butan-2-one related compounds:

• 4-(6-methoxy-2-naphthyl)but-3-en-2-one
• 4-(6-methoxy-2-naphthyl)-3-methylbutan-2-one
• 5-(6-methoxy-2-naphthyl)pentan-3-one

It may also be used in the synthesis of the following chalcone derivatives:

• (2E)-1-(2-hydroxyphenyl)-3-(6-methoxy-2-naphthyl)prop-2-en-1-one
• (2E)-1-(2-chloropyridin-4-yl)-3-(6-methoxy-2-naphthyl)prop-2-en-1-one
• (2E)-3-(6-methoxy-2-naphthyl)-1-pyridin-4-ylprop-2-en-1-one
• (2E)-1-(2,4-dichlorophenyl)-3-(6-methoxy-2-naphthyl)prop-2-en-1-one

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 4587, 1988 DOI: 10.1021/jo00254a035

General Description

6-Methoxy-2-naphthaldehyde can be prepared by reacting 2-bromo 6-methoxy naphthalene with triethylorthoformate via Grignard reaction. Its crystals belong to the orthorhombic space group, P212121 and shows excellent NLO (non-linear optical) property.

Flammability and Explosibility

Not classified

6-Methoxy-2-naphthaldehyde(3453-33-6)Related Product Information

• 6-methoxy-1-tetralone
• 2-Bromo-6-methoxynaphthalene
• 2-Acetyl-6-methoxynaphthalene
• 6-Methoxy-2-naphthaldehyde
• CHROMOMYCIN A3
• 6-METHOXY-2-NAPHTHOIC ACID
• 6-ACETOXY-2-NAPHTHOIC ACID
• 2-ACETYL-5-BROMO-6-METHOXYNAPHTHALENE
• MITHRAMYCIN A
• 6'-Methoxy-2'-propiononaphthone
• 3,8-DIMETHOXY-2-NAPHTHALDEHYDE
• 2-METHOXY-1-NAPHTHALDEHYDE
• 4-METHOXY-1-NAPHTHALDEHYDE
• 2-Naphthaldehyde
• 1-(5-BROMO-6-METHOXY-2-NAPHTHYL)-1-PROPANONE
• 5,6,7-trimethoxy-2-naphthoic acid
• 2-methoxy-1-naphthaldehyde thiosemicarbazone
• 1,2,3,4-Tetrahydro-6-methoxy-2-naphthaldehyde