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8-debenzoylpaeoniflorin

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8-debenzoylpaeoniflorin Basic information

Product Name:
8-debenzoylpaeoniflorin
Synonyms:
  • 8-debenzoylpaeoniflorin
  • 8-O-Debenzoylpaeoniflorin
  • desbenzoylpaeoniflorin
  • β-D-Glucopyranoside, (1aR,2S,3aR,5R,5aR,5bS)-tetrahydro-5-hydroxy-5b-(hydroxymethyl)-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl
  • 8-O-Debenzoylpaeonif
CAS:
23532-11-8
MF:
C16H24O10
MW:
376.36
Mol File:
23532-11-8.mol
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8-debenzoylpaeoniflorin Usage And Synthesis

Uses

8-Debenzoylpaeoniflorin, a monoterpene glycoside, is a natural product that could be isolated from the dried root of Paeonia lactiflora Pall. 8-Debenzoylpaeoniflorin has antihyperglycemic activity[1].

in vivo

8-Debenzoylpaeoniflorin (1-10 mg/kg; i.v.; single dose) has antihyperglycemic activity and decreases plasma glucose levels in STZ-diabetic rats[1].

Animal Model:Male Wistar STZ-diabetic rats (210-250g)[1]
Dosage:1, 5, and 10 mg/kg
Administration:Intravenous injection, single dose
Result:Decreased plasma glucose levels in a time- and dose-dependent manner in STZ-diabetic rats.

References

[1] Hsu FL, et, al. Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora. Planta Med. 1997 Aug;63(4):323-5. DOI:10.1055/s-2006-957692

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