trans-4-Aminocyclohexanol Chemical Properties

Melting point:

108-113°C

Boiling point:

127 °C / 14mmHg

Density 

0.9837 (rough estimate)

refractive index 

1.4713 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Crystals

pka

15.12±0.40(Predicted)

color 

White to almost white

Water Solubility 

Soluble in water.

Sensitive 

Hygroscopic

LogP

-0.4

CAS DataBase Reference

27489-62-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C,Xn

Risk Statements 

36/37/38-34-41-37/38-22

Safety Statements 

26-37/39-45-36/37/39-39

RIDADR 

3259

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

29221990

MSDS

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trans-4-Aminocyclohexanol Usage And Synthesis

Description

Trans-4-Aminocyclohexanol is also named as Cis-4-Aminocyclohexanol. It was a medical intermediate of ambroxol, which is used in the treatment of respiratory diseases associated with viscid or excessive mucus.¹ It is used as a raw material in organic synthesis, such as in the synthesis of N-substituted 7-azabicyclo [2.2.1] hepatanes, which are good substrates for microbial oxidation of unactivated carbons by B.bassiana.²

Reference

1. Y. Jian, Improved Process of the Synthesis of Trans-4-aminocyclohexanol, Fine Chemicals, 2000, vol. 2
2. H. F. Olivo, M. S. Hemenway, M. H. Gezginci, Synthesis and Microbial Hydroxylation of Some Azabicycloalkanes, Tetrahedron Letters, 1998, vol. 39, pp. 1309-1312

Chemical Properties

white to light yellow crystal powder

Uses

trans-4-aminocyclohexanol be used as organic intermediates.

Uses

trans-4-Aminocyclohexanol is used as raw material in organic synthesis and is an important intermediate in the synthesis of drugs such as Ambroxol hydrochloride. It can react with butyric acid-(2-chloro-ethyl ester) to get butyric acid 4-amino-cyclohexyl ester. This reaction needs catalytic agent Aspergillus niger lipase and solvent 2-methyl-butan-2-ol.

trans-4-Aminocyclohexanol(27489-62-9)Related Product Information

• Molasses
• 1-Methylcyclohexanol
• Cyclohexanol
• trans-4-Aminocyclohexanol hydrochloride
• 2-Aminocyclohexanol
• trans,trans-2,4-Undecadienal
• Cyclamic acid
• 4-Aminocyclohexanol
• Cyclohexanol, 4-amino-1-methyl-, trans- (9CI)
• (E,E)-2,4-Hexadien-1-ol
• TRANS-4-AMINO-CYCLOHEXANE CARBOXYLIC ACID HYDROCHLORIDE
• trans-4-Aminocyclohexanecarbonitrile
• Methyl trans-4-AMinocyclohexanecarboxylate Hydrochloride
• Trans-4-Propylcyclohexyl-Benzene
• Trans-1-(bromomethyl)-4-propylcyclohexane
• 4-(trans-4-Propylcyclohexyl)phenol
• trans-4-(4n-Heptylcyclohexyl)phenol
• trans-4-ethylcyclohexylbenzene