2-Oxazolidone Chemical Properties

Melting point:

83-87 °C(lit.)

Boiling point:

220 °C48 mm Hg(lit.)

Density 

1.2736 (rough estimate)

refractive index 

1.4940 (estimate)

Flash point:

220°C/48mm

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly, Heated), Methanol (Slightly)

pka

12.78±0.20(Predicted)

form 

Crystals or Powder

color 

Off-white to yellow-beige

Water Solubility 

Soluble in water.

BRN 

106251

CAS DataBase Reference

497-25-6(CAS DataBase Reference)

NIST Chemistry Reference

Oxazolidin-2-one(497-25-6)

EPA Substance Registry System

2-Oxazolidinone (497-25-6)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36-43-40-36/37/38

Safety Statements 

26-36/37-37-36

WGK Germany 

3

RTECS 

RQ2450000

TSCA 

Yes

HS Code 

29322980

Toxicity

TDLo orl-mus: 1000 mg/kg:ETA BCPCA62,168,59

MSDS

• Language:English Provider:Oxazolidin-2-one
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Oxazolidone Usage And Synthesis

Chemical Properties

off-white to yellow-beige crystals or powder

Uses

An oxazole derivative used as an antibiotic. It is also used in the preparation of compounds with antitumor activity. A metabolite of Furazolidone (F864100).

Uses

As an oxazole derivative used as an antibiotic, 2-Oxazolidone is also used in the preparation of compounds with antitumor activity and as a metabolite of Furazolidone (F864100).

Definition

ChEBI: An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.

Safety Profile

Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise it from *benzene, dichloroethane, CHCl3 or EtOH. It is a cyclic urethane, and as such it is not very stable. [Katritzky et al. J Chem Soc Perkin II 145 1990, Beilstein 27 H 135, 27 II 259, 27 III/IV 2516.]

2-Oxazolidone (497-25-6)Related Product Information

• Oxadixyl
• Bis(2-oxo-3-oxazolidinyl)phosphinic chloride
• 3-PHENYL-2-OXAZOLIDINONE
• 3-(2'-HYDROXYETHYL)-2-OXAZOLIDONE,N-Hydroxyethyl-2-oxazolidone
• 3-((5-Nitrofurylidene)amino)-2-oxazolidone,3-(5'-Nitrofurfuralamino)-2-oxazolidone,3-(5’-nitrofurfuralamino)-2-oxazolidon
• 5-CHLOROMETHYL-2-OXAZOLIDINONE
• (S)-(+)-4-PHENYL-2-OXAZOLIDONE
• (4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone
• (S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone
• S-4-Isopropyl-2-oxazolidone
• 3-TRIMETHYLSILYL-2-OXAZOLIDONE
• 3-AMINO-2-OXAZOLIDINONE
• 5,5-Dimethyloxazolidine-2,4-dione
• (R)-(+)-4-BENZYL-2-OXAZOLIDONE
• 3-Methyl-2-oxazolidone
• 3-Acetyl-1-chlorocarbonyl-2-imidazolidone
• 5-methylthiomethyl-3-(5-nitrofurfurylideneamino)-2-oxazolidone
• N-PROPIONYL-(4S,5R)-4-METHYL- 5-PHENYL-2-OXAZOLIDINONE