2,5-Dihydroxybenzaldehyde Chemical Properties

Melting point:

97-99 °C (lit.)

Boiling point:

213.5°C (rough estimate)

Density 

1.2667 (rough estimate)

refractive index 

1.4797 (estimate)

storage temp. 

Store below +30°C.

solubility 

13.8g/l soluble

pka

8.89±0.18(Predicted)

form 

Crystalline Powder

color 

Yellow to khaki-green

Water Solubility 

soluble

Sensitive 

Air Sensitive

BRN 

1363961

InChIKey

CLFRCXCBWIQVRN-UHFFFAOYSA-N

LogP

0.540

CAS DataBase Reference

1194-98-5(CAS DataBase Reference)

NIST Chemistry Reference

2,5-Dihydroxybenzaldehyde(1194-98-5)

EPA Substance Registry System

Benzaldehyde, 2,5-dihydroxy- (1194-98-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-43

Safety Statements 

26-36/37/39-37/39-26,37/39-36

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29124990

MSDS

• Language:English Provider:2,5-Dihydroxybenzaldehyde
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,5-Dihydroxybenzaldehyde Usage And Synthesis

Description

2,5-Dihydroxybenzaldehyde is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activity.

Chemical Properties

yellow to khaki-green crystalline powder

Uses

2,5-Dihydroxybenzaldehyde (cas# 1194-98-5) is a compound useful in organic synthesis.

Application

2,5-Dihydroxybenzaldehyde is a is a natural phenol found in the heartwoods of Pseudolarix amabilis, it is a tyrosine kinase inhibitor. 2,5-Dihydroxybenzaldehyde has antimicrobial activity and is mostly used in experimental studies for the preparation of Schiff base derivatives and bioanodes for glucose fuel cells.

Definition

ChEBI: 2,5-dihydroxybenzaldehyde is a dihydroxybenzaldehyde carrying hydroxy groups at positions 2 and 5. It has a role as a Penicillium metabolite, a mouse metabolite and a human metabolite.

Preparation

Add 80 mmol of dry paraformaldehyde to a mixture of 12 mmol of the phenol derivative and 2.5 mmol of MgO nanocrystalline (0.1 g). Expose the resulting mixture under microwave irradiation with a power of 650 W. Monitor the progress of the reaction by thin layer chromatography (TLC) developed by n-hexane : ethyl acetate (8 : 2). Add 100 mL of sulfuric acid (15% w/w) to the reaction mixture and heated at 50 °C for 15 min. Cool the reaction mixture to room temperature. Extract the product by dichloromethane (2 x 50 mL). Dry the organic layer over anhydrous magnesium sulphate. Evaporate the solution resulting from filtration to obtain the crude product. Purify the other product by column chromatography using n-hexane : ethyl acetate (95 : 5 to 70 : 30).

2,5-Dihydroxybenzaldehyde(1194-98-5)Related Product Information

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• 2,5-DIMETHOXYBENZOYL CHLORIDE
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• 2',5'-Dimethoxyacetophenone
• 2,3-DIHYDRO-9,10-DIHYDROXY-1,4-ANTHRACENEDIONE
• ACID GREEN 41
• 2,5-Dihydroxybenzaldehyde
• 2-BROMO-2',5'-DIMETHOXYACETOPHENONE
• 2,5-Dihydroxybenzoic acid