L-Tyr-NCA Chemical Properties

Melting point:

>168°C (dec.)

Density 

1.423

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

9.14±0.40(Predicted)

color 

Light Beige to Pale Orange

InChI

InChI=1S/C10H9NO4/c12-7-3-1-6(2-4-7)5-8-9(13)15-10(14)11-8/h1-4,8,12H,5H2,(H,11,14)/t8-/m0/s1

InChIKey

HOEAPYNDVBABMC-QMMMGPOBSA-N

SMILES

O1C(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O

L-Tyr-NCA Usage And Synthesis

Uses

L-Tyr-NCA is used as a reactant in the synthesis of peptides. Peptides such as glutamine penefit in optimum protein utilization for post-injury conditions.

Uses

N-Carbonyl-L-tyrosine Anhydride (L-Tyr-NCA) is used as a reactant in the synthesis of peptides. Peptides such as glutamine penefit in optimum protein utilization for post-injury conditions.

Synthesis

L-tyrosine (1.0 g, 6.1 mmol, 1 equiv) was added to a thick-walled pressure bottle, and then 15 mL of analytically pure tetrahydrofuran, propylene oxide (4.3 mL, 61 mmol, 10 equiv), and triphosgene (897 mL) were added. Stir at room temperature for 7 hours. The result solution was Washed, dried, and crystallized. After that, the final product L-tyrosine nitrogen-carboxyl anhydride (L-Tyr-NCA) was obtained.