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5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine

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5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine Basic information

Product Name:
5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
Synonyms:
  • N2-ISOBUTYRYL-5 , O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2
  • 5'-O-[Bis(4-Methoxyphenyl)phenylMethyl]-2'-O-(2-Methoxyethyl)-N-(2-Methyl-1-oxopropyl)guanosine
  • 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-N2-isobutyrylguanosine
  • N2-iso-Butyroyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)guanosine
  • N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
  • Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-
  • 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine
  • N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-(2-methoxyethoxy)oxolan-2-yl]-6-oxo-3H-purin-2-yl]-2-methylpropanamide
CAS:
251647-50-4
MF:
C38H43N5O9
MW:
713.78
Product Categories:
  • Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
  • Modified(deoxy)nucleoside
Mol File:
251647-50-4.mol
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5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine Chemical Properties

Melting point:
112.5-126.6 °C(Solv: hexane (110-54-3))
Density 
1.33±0.1 g/cm3(Predicted)
pka
9.16±0.20(Predicted)
InChI
InChI=1/C38H43N5O9/c1-23(2)34(45)41-37-40-33-30(35(46)42-37)39-22-43(33)36-32(50-20-19-47-3)31(44)29(52-36)21-51-38(24-9-7-6-8-10-24,25-11-15-27(48-4)16-12-25)26-13-17-28(49-5)18-14-26/h6-18,22-23,29,31-32,36,44H,19-21H2,1-5H3,(H2,40,41,42,45,46)/t29-,31-,32-,36-/s3
InChIKey
XDLPRZLZAFJSMA-JKILKRELNA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](OCCOC)[C@@H]1O |&1:25,27,44,50,r|
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5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine Usage And Synthesis

Uses

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine is an oligonucleotide analogue which is being researched for the treatment of a wide variety of diseases, cancers, and conditions.

Definition

5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine is an antiviral monophosphate nucleoside. It is a modified nucleic acid analogue that acts as an activator of ribonucleotide reductase and DNA polymerase. The anticancer activity of this product may be due to its ability to inhibit the synthesis of diphosphate nucleotides.

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