7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Basic information
- Product Name:
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- Synonyms:
-
- Ivabradine Impurity 13
- 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one
- 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- 2H-3-Benzazepin-2-one,1,3-dihydro-7,8-diMethoxy-
- 1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one
- 7,8-diMethoxy-2,3-dihydro-1H-3-benzazepin-2-one
- 7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one
- CAS:
- 73942-87-7
- MF:
- C12H13NO3
- MW:
- 219.24
- EINECS:
- 456-160-0
- Product Categories:
-
- Aromatics
- Heterocycles
- Intermediates
- Mol File:
- 73942-87-7.mol
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Chemical Properties
- Melting point:
- 244.0 to 248.0 °C
- Boiling point:
- 455.8±45.0 °C(Predicted)
- Density
- 1.167
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- 13.29±0.20(Predicted)
- color
- Off-White to Pale Beige
- LogP
- 1.23 at 23℃ and pH6.47
- Surface tension
- 71mN/m at 36.9mg/L and 19℃
- CAS DataBase Reference
- 73942-87-7(CAS DataBase Reference)
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Usage And Synthesis
Uses
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.
Application
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.
Definition
ChEBI: 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one is a benzazepine.
Synthesis
1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.
2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.
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7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one(73942-87-7)Related Product Information
- Ivabradine Impurity 70
- 4,5-Dimethoxy-1-cyanobenzocyclobutane
- (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
- (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one
- 3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one
- 1204612-29-2
- 3,4-dimethoxy-N-methylbenzamide
- 8-DeMethyl Ivabradine
- N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide
- Hydroxy Ivabradine
- (3,4-Dimethoxyphenyl)acetic acid
- C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE
- Ivabradine Impurity 49
- 1132079-01-6
- N-DeMethyl Ivabradine Hydrochloride
- Ivabradine Impurity 1 Hydrochloride
- 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one
- 7-DeMethyl Ivabradine