Basic information Safety Supplier Related

H-Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys-OH (Cys3-Cys9)

Basic information Safety Supplier Related

H-Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys-OH (Cys3-Cys9) Basic information

Product Name:
H-Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys-OH (Cys3-Cys9)
Synonyms:
  • CRUSTACEAN CARDIOACTIVE PEPTIDE, CCAP
  • H-Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys-OH (Cys3-Cys9)
  • PRO-PHE-CYS-ASN-ALA-PHE-THR-GLY-CYS(DISULFIDE BRIDGE CYS3-CYS9)
  • L-Cysteine, L-prolyl-L-phenylalanyl-L-cysteinyl-L-asparaginyl-L-alanyl-L-phenylalanyl-L-threonylglycyl-
  • Crustacean cardioactive peptide, free acid
  • Crustacean Cardioactive Peptide , CCAPfreeacid
CAS:
309247-84-5
MF:
C42H58N10O12S2
MW:
959.1
Product Categories:
  • Peptide
Mol File:
309247-84-5.mol
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H-Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys-OH (Cys3-Cys9) Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (52.13 mM);Water : < 0.1 mg/mL (insoluble)
form 
Solid
color 
White to off-white
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H-Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys-OH (Cys3-Cys9) Usage And Synthesis

Uses

Crustacean cardioactive peptide, free acid is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean cardioactive peptide, free acid also modulates the neuronal activity in other arthropods.

in vivo

CCAP, FMRFamide and SALDKNFMRFamide increase the mosquito antennal accessory pulsatile organ (APO) and heart contraction rates, increase hemolymph flow velocity in the antennal space[1].

References

[1] Suggs JM, et al. CCAP and FMRFamide-like peptides accelerate the contraction rate of the antennal accessory pulsatile organs (auxiliary hearts) of mosquitoes. J Exp Biol. 2016 Aug 1;219(Pt 15):2388-95. DOI:10.1242/jeb.141655
[2] Moris-Sanz M, et al. The study of the Bithorax-complex genes in patterning CCAP neurons reveals a temporal control of neuronal differentiation by Abd-B. Biol Open. 2015 Aug 14;4(9):1132-42. DOI:10.1242/bio.012872

H-Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys-OH (Cys3-Cys9)Supplier

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