H-Gly-Arg-pNA Chemical Properties

Density 

1.50±0.1 g/cm3(Predicted)

pka

12.48±0.70(Predicted)

Sequence

Gly-{Arg-pNA}

H-Gly-Arg-pNA Usage And Synthesis

Chemical Properties

Light yellow powder

Uses

Gly-Arg-pNA is a fluorogenic substrate for the measurement of protease activity. Gly-Arg-pNA undergoes hydrolysis and releases the fluorescent product p-nitroaniline. p-nitroaniline is in a fluorescent state under ultraviolet light irradiation and can emit a fluorescent signal [1][2].

References

[1] Hutchinson DW, et, al. The preparation and properties of immobilised dipeptidyl-aminopeptidase I (cathepsin C). Biochim Biophys Acta. 1987 Nov 5;916(1):1-4. DOI:10.1016/0167-4838(87)90203-2
[2] Potempa J, et, al. Comparative properties of two cysteine proteinases (gingipains R), the products of two related but individual genes of Porphyromonas gingivalis. J Biol Chem. 1998 Aug 21;273(34):21648-57. DOI:10.1074/jbc.273.34.21648

H-Gly-Arg-pNA(103192-40-1)Related Product Information

• H-GLU-PNA
• H-GAMMA-GLU-VAL-OH
• H-GLY-GLU-PNA
• H-THR-THR-PNA
• H-HIS-PNA
• glutamyl-glycyl-arginine-4-nitroanilide