Disodium edetate dihydrate Chemical Properties

Melting point:

250 °C (dec.)(lit.)

Boiling point:

>100 °C

Density 

1.01 g/mL at 25 °C

refractive index 

n20/D 1.363

FEMA 

4520 | ETHYLENEDIAMINETETRAACETIC ACID DISODIUM SALT

Flash point:

>100℃

storage temp. 

room temp

solubility 

3  M NaOH: 100 mg/mL

form 

crystalline

pka

pK1:1.99;pK2:2.67;pK3:6.16;pK4:10.26 (25°C)

color 

≤5 (0.5 M)(APHA)

PH

4.0-5.5 (25℃, 0.1M in H2O)

Odor

Odorless

PH Range

4 - 5 at 10 g/l at 23 °C

Water Solubility 

soluble

λmax

λ: 260 nm Amax: 0.145
λ: 280 nm Amax: 0.025

BRN 

3900609

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

QCDUWWPHAVXXQS-UHFFFAOYSA-L

CAS DataBase Reference

6381-92-6(CAS DataBase Reference)

EPA Substance Registry System

Ethylenediaminetetraacetic acid disodium salt dihydrate (6381-92-6)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36-52/53-36/38-36/37/38-22

Safety Statements 

26-61-37/39-36/37/39-36

WGK Germany 

2

RTECS 

AH4025000

F 

3

TSCA 

Yes

HS Code 

29224995

Toxicity

LD50 orally in Rabbit: > 2000 mg/kg

MSDS

• Language:English Provider:Disodium edetate dihydrate
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Disodium edetate dihydrate Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder.

Uses

Chelating agent; sequestering agent

Uses

Ethylenediamine tetraacetic acid disodium dihydrate is used as chelating agent for metals and as pharmaceutic aid (chelating agent); as preservative in cosmetic products; anticoagulant.

Uses

Ethylenediaminetetraacetic acid disodium salt dihydrate is used as a chelator of divalent cations. It inhibits enzymes such as metalloproteases that require divalent cations for activity. It is also used in chelation therapy. It acts as a sequestering agent in shampoos, cleaners and other personal care products and serves as an anticoagulant for blood samples.

Definition

ChEBI: A hydrate that is the dihydrate form of EDTA disodium salt.

General Description

Ethylenediaminetetraacetic acid disodium salt dehydrate is designated as Molecular Biology grade and is suitable for molecular biology applications. It has been analyzed for the presence of nucleases and proteases.

Biochem/physiol Actions

Zinc-dependent metalloproteinases, as well as other proteases that are stabilized by calcium, can be effectively inhibited by chelation of divalent metal ions with EDTA. Other chelators such as EGTA, specific for calcium, and 1,10-phenanthroline, highly specific for zinc, can be used to target these two different types of proteases.

Purification Methods

Analytical reagent grade material can be used as primary standard after drying at 80o. Commercial grade material can be purified by crystallisation from water or by preparing a 10% aqueous solution at room temperature, then adding ethanol slowly until a slight permanent precipitate is formed, filtering, and adding an equal volume of ethanol. The precipitate is filtered off onto a sintered-glass funnel, is washed with acetone, followed by diethyl ether, and dried in air overnight to give the dihydrate. Drying at 80o for at least 24hours converts it to the anhydrous form. [Beilstein 4 IV 2451.]

Disodium edetate dihydrate(6381-92-6)Related Product Information

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• ETHYLENEDIAMINETETRAACETIC ACID CALCIUM DISODIUM SALT HYDRATE
• Ethylenediaminetetraacetic acid trisodium salt solution
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• ETHYLENEDIAMINETETRAACETIC ACID TRIPOTASSIUM SALT DIHYDRATE
• Ethylenediaminetetraacetic acid dipotassium salt dihydrate
• Manganese disodium EDTA trihydrate
• Ferric ammonium EDTA
• Edta Disodium Salt Dihydrate
• Ethylenediaminetetraacetic Acid Disodium Salt Dihydrate