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Disodium edetate dihydrate

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Disodium edetate dihydrate Basic information

Product Name:
Disodium edetate dihydrate
Synonyms:
  • aceticacid,(ethylenedinitrilo)tetra-,disodiumsalt,dihydrate
  • disodiumedtadihydrate
  • ethylenediaminetetraaceticacidsodiumsaltdihydrate(disodiumedta
  • ethylenediaminetetraaceticacidsodiumsaltdihydrate(disodiumedtadihydrate)
  • glycine,n,n’-1,2-ethanediylbis(n-(carboxymethyl)-,disodiumsalt,dihydrate
  • Glycine,N,N’-1,2-ethanediylbis[N-(carboxymethyl)-,disodiumsalt,dihydrate
  • 1,2-DIAMINOETHANE-N,N,N',N'-TETRA-ACETIC ACID
  • EDTA TITRANT
CAS:
6381-92-6
MF:
C10H19N2NaO9
MW:
334.26
EINECS:
613-386-6
Product Categories:
  • Cosmetic or Industrial Grade
  • organic amine
  • Analytical Chemistry
  • Organic Chemicals
  • reagent
  • Food Additives
  • Chelating Reagents
  • Complexones
  • EDTA Analogs
Mol File:
6381-92-6.mol
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Disodium edetate dihydrate Chemical Properties

Melting point:
250 °C (dec.)(lit.)
Boiling point:
>100 °C
Density 
1.01 g/mL at 25 °C
FEMA 
4520 | ETHYLENEDIAMINETETRAACETIC ACID DISODIUM SALT
refractive index 
n20/D 1.363
Flash point:
>100℃
storage temp. 
room temp
solubility 
3  M NaOH: 100 mg/mL
pka
pK1:1.99;pK2:2.67;pK3:6.16;pK4:10.26 (25°C)
form 
crystalline
color 
≤5 (0.5 M)(APHA)
Odor
Odorless
PH
4.0-5.5 (25℃, 0.1M in H2O)
PH Range
4 - 5 at 10 g/l at 23 °C
Water Solubility 
soluble
λmax
λ: 260 nm Amax: 0.145
λ: 280 nm Amax: 0.025
BRN 
3900609
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
QCDUWWPHAVXXQS-UHFFFAOYSA-L
CAS DataBase Reference
6381-92-6(CAS DataBase Reference)
EPA Substance Registry System
Ethylenediaminetetraacetic acid disodium salt dihydrate (6381-92-6)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36-52/53-36/38-36/37/38-22
Safety Statements 
26-61-37/39-36/37/39-36
WGK Germany 
2
RTECS 
AH4025000
3
TSCA 
Yes
HS Code 
29224995
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg

MSDS

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Disodium edetate dihydrate Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder.

Uses

Chelating agent; sequestering agent

Uses

Ethylenediamine tetraacetic acid disodium dihydrate is used as chelating agent for metals and as pharmaceutic aid (chelating agent); as preservative in cosmetic products; anticoagulant.

Uses

Ethylenediaminetetraacetic acid disodium salt dihydrate is used as a chelator of divalent cations. It inhibits enzymes such as metalloproteases that require divalent cations for activity. It is also used in chelation therapy. It acts as a sequestering agent in shampoos, cleaners and other personal care products and serves as an anticoagulant for blood samples.

Definition

ChEBI: A hydrate that is the dihydrate form of EDTA disodium salt.

General Description

Ethylenediaminetetraacetic acid disodium salt dehydrate is designated as Molecular Biology grade and is suitable for molecular biology applications. It has been analyzed for the presence of nucleases and proteases.

Biochem/physiol Actions

Zinc-dependent metalloproteinases, as well as other proteases that are stabilized by calcium, can be effectively inhibited by chelation of divalent metal ions with EDTA. Other chelators such as EGTA, specific for calcium, and 1,10-phenanthroline, highly specific for zinc, can be used to target these two different types of proteases.

Purification Methods

Analytical reagent grade material can be used as primary standard after drying at 80o. Commercial grade material can be purified by crystallisation from water or by preparing a 10% aqueous solution at room temperature, then adding ethanol slowly until a slight permanent precipitate is formed, filtering, and adding an equal volume of ethanol. The precipitate is filtered off onto a sintered-glass funnel, is washed with acetone, followed by diethyl ether, and dried in air overnight to give the dihydrate. Drying at 80o for at least 24hours converts it to the anhydrous form. [Beilstein 4 IV 2451.]

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