tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate Chemical Properties

Boiling point:

388.0±42.0 °C(Predicted)

Density 

1.200±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

14.81±0.20(Predicted)

Appearance

Off-white to yellow Solid

InChI

InChI=1S/C11H17N3O2/c1-11(2,3)16-10(15)14-5-4-9-8(7-14)6-12-13-9/h6H,4-5,7H2,1-3H3,(H,12,13)

InChIKey

BHYPERDTLBCHAE-UHFFFAOYSA-N

SMILES

C1N(C(OC(C)(C)C)=O)CCC2NN=CC1=2

Safety Information

HS Code 

2933399990

tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate Usage And Synthesis

Synthesis

General procedure for the synthesis of tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate from the compound (CAS: 1310796-19-0): to tert-butyl (Z)-3-((dimethylamino)methylene)-4-oxo-piperidine-1-carboxylate (8.8 g, 34.6 mmol) in ethanol (EtOH, 50 mL) hydrazine hydrate (N2H4-H2O, 200 mL) was slowly added to the solution at 0°C. The reaction mixture was stirred at 20°C for 12 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The resulting residue was isolated and purified by column chromatography to afford the target product tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate (7 g, 95% yield). The product was analyzed by LCMS and showed m/z: 224.2 [M + H]+.

References

[1] Patent: WO2015/200677, 2015, A2. Location in patent: Paragraph 00806; 00807

tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate(230301-11-8)Related Product Information

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