Ginsenoside Rf
Ginsenoside Rf Basic information
- Product Name:
- Ginsenoside Rf
- Synonyms:
-
- GINSENOSIDE RF
- PANAXOSIDE RF
- GINSENOSIDE Rf hplc
- GINSENOSIDE RF WITH HPLC
- droxydammar-24-en-6-yl 2-O-β-D-glucopyranosyl-
- β-D-Glucopyranoside, (3β,6α,12β)-3,12,20-trihy
- (3β,6α,12β)-3,12,20-Trihydroxydammar-24-en-6-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
- (20S)-6α-(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyloxy)-5α-dammara-24-ene-3β,12β,20-triol
- CAS:
- 52286-58-5
- MF:
- C42H72O14
- MW:
- 801.02
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Saponins
- Ginsenoside series
- Mol File:
- 52286-58-5.mol
Ginsenoside Rf Chemical Properties
- Melting point:
- 197～198℃
- Boiling point:
- 912.3±65.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Methanol (Slightly), Pyridine (Slightly)
- form
- Solid
- pka
- 12.85±0.70(Predicted)
- color
- White to Off-White
- InChIKey
- UZIOUZHBUYLDHW-CGJOLZHFNA-N
- LogP
- 3.560 (est)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 2-45-24/25
- WGK Germany
- 3
- RTECS
- LY9536900
- HS Code
- 29389090
Ginsenoside Rf Usage And Synthesis
Chemical Properties
White to off-white solid
Uses
Ginsenoside Rf is an anti-arthritic agent, attenuating collagen-induced arthritis in mice.
Definition
ChEBI: Ginsenoside Rf is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite, an apoptosis inducer and an antineoplastic agent. It is a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a beta-D-glucoside, a disaccharide derivative, a ginsenoside, a tetracyclic triterpenoid, a 20-hydroxy steroid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.
in vivo
Since inhibition of Ca2+ channels in sensory neurons contributes to antinociception by opioids, analgesic actions of Ginsenoside Rf are tested. Dose-dependent antinociception is found by systemic administration of Ginsenoside Rf in mice using two separate assays of tonic pain: in the acetic acid abdominal constriction test, the ED50 is 56±9 mg/kg, a concentration similar to those reported for aspirin and acetaminophen in the same assay; in the tonic phase of the biphasic formalin test, the ED50 is 129±32 mg/kg[2].
IC 50
N-type calcium channel
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