2-CHLORO-4-(METHYLSULFONYL)ANILINE CAS#: 13244-35-4

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2-CHLORO-4-(METHYLSULFONYL)ANILINE

Basic information Safety Supplier Related

2-CHLORO-4-(METHYLSULFONYL)ANILINE Basic information

Product Name:

2-CHLORO-4-(METHYLSULFONYL)ANILINE

Synonyms:

2-chloro-4-(methylsulfonyl)-anilin
2-chloro-4-(methylsulfonyl)-benzenamin
4-amino-3-chlorofenylomethylosulfon
4-amino-3-chlorophenylmethylsulfone
4-amino-3-chlorophenylmethylsulphone
TIMTEC-BB SBB003494
2-CHLORO-4-(METHYLSULFONYL)ANILINE
2-CHLORO-4-METHYLSULPHONYLANILINE

CAS:

13244-35-4

MF:

C7H8ClNO2S

MW:

205.66

EINECS:

236-225-8

Mol File:

13244-35-4.mol

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2-CHLORO-4-(METHYLSULFONYL)ANILINE Chemical Properties

Melting point:: 191-198 °C
Boiling point:: 400.1±45.0 °C(Predicted)
Density: 1.2326 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: 2-8°C
pka: -0.60±0.10(Predicted)
form: Crystalline Powder
color: Pale purple to gray-brown
CAS DataBase Reference: 13244-35-4(CAS DataBase Reference)
EPA Substance Registry System: Benzenamine, 2-chloro-4-(methylsulfonyl)- (13244-35-4)

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Safety Information

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
Hazard Note: Irritant
HS Code: 29309099

MSDS

Language:English Provider:ACROS

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2-CHLORO-4-(METHYLSULFONYL)ANILINE Usage And Synthesis

Chemical Properties

pale purple to grey-brown crystalline powder

Uses

2-Chloro-4-methylsulphonylaniline can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and pharmaceutical and chemical production processes.

Synthesis

A mixture of 2-chloro-4-methylsulfonyl-1- nitro-benzene (4.5 g, 19.10 mmol, 1 eq.) in EtOH (40 mL) and a saturated NH4Cl solution (10 mL) was heated to 90 °C, and then Fe (3.20 g, 57.29 mmol, 3 eq.) was added in one portion. The reaction mixture was stirred at 90 °C for 1 h, after which time TLC analysis (PE:EtOAc = 1:1, Rf(starting material) = 0.7, Rf(product) = 0.31) indicated that the reaction was complete. The reaction was diluted with water (50 mL) and extracted with EtOAc (100 mL x 3). The combined organic layers were washed with water (50 mL x 3) and brine (50 mL x 2), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography (SiO2, PE:EtOAc = 4:1 to 2:1) to provide 2-chloro-4-methylsulfonyl-aniline (3.7 g, 17.99 mmol, 94.21% yield) as an off-white solid.

2-CHLORO-4-(METHYLSULFONYL)ANILINESupplier

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