1-Bromo-3,4-dichlorobenzene Chemical Properties

Melting point:

24-25 °C(lit.)

Boiling point:

124 °C33 mm Hg(lit.)

Density 

1.761 g/mL at 25 °C(lit.)

vapor pressure 

0.6-25Pa at 20-50℃

refractive index 

n20/D 1.599(lit.)

Flash point:

189 °F

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid After Melting

color 

Clear slightly yellow

Water Solubility 

insoluble

BRN 

1635735

LogP

4.3 at 25℃ and pH7

CAS DataBase Reference

18282-59-2(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 4-bromo-1,2-dichloro-(18282-59-2)

EPA Substance Registry System

Benzene, 4-bromo-1,2-dichloro- (18282-59-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-28A

WGK Germany 

3

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29039990

MSDS

• Language:English Provider:1-Bromo-3,4-dichlorobenzene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-Bromo-3,4-dichlorobenzene Usage And Synthesis

Chemical Properties

colorless to light yellow liqui

General Description

4-Bromo-1,2-dichlorobenzene participates in the synthesis of N-arylated sultams.

Synthesis

General procedure for the synthesis of 4-bromo-1,2-dichlorobenzene from o-dichlorobenzene: 26.2 g of 1,2-dichlorobenzene was mixed with 2.75 g of iron powder, heated to 45 °C and 26 g of bromine was added slowly and dropwise at a rate of 0.2 mL/min. The reaction was completed after the dropwise addition process lasted for 2 hours. At the end of the reaction, the reaction was quenched by the addition of sodium sulfite solution and the reaction mixture was extracted with dichloromethane and the solvent was subsequently removed to give 41.6 g of crude product. Compositional analysis of the crude product showed the presence of 5.5% of 1,2-dichlorobenzene, 2.1% of 2,3-dichlorobromobenzene isomers and 0.6% of high-boiling substances (mainly dibrominated or polybrominated products). The unreacted 1,2-dichlorobenzene was recovered by distillation purification by first collecting the 100-110 °C fraction at pressures of -0.09 to -0.1 MPa, followed by collecting the 160-165 °C fraction at the same pressures to give 33.2 g of 4-bromo-1,2-dichlorobenzene with a purity of 98.5% and a molar yield of 90.3%.

References

[1] Patent: CN107915659, 2018, A. Location in patent: Paragraph 0032-0034; 0037-0039; 0042-0044; 0047-0054
[2] Organic and Biomolecular Chemistry, 2003, vol. 1, # 14, p. 2506 - 2511

1-Bromo-3,4-dichlorobenzene(18282-59-2)Related Product Information

• 2-Bromofluorobenzene
• Bromoxynil octanoate
• 2-Bromobenzonitrile
• 1,2-Dibromobenzene
• 3-Bromoanisole
• 1,2-Dichlorobenzene
• 1,4-Dichlorobenzene
• Brompheniramine hydrogen maleate
• 4-Bromoanisole
• Brompheniramine
• BROMO(2-)-4-DICHLOROBENZENE,1-Bromo-2,4-dichlorobenzene, 98+%,1-BROMO-2,4-DICHLOROBENZENE / 2,4-DICHLOROBROMOBENZENE,1-BROMO-2,4-DICHLOROBENZENE
• 1-BROMO-3,5-DICHLOROBENZENE
• p-Dichlorobenzene
• 1-Bromo-4,5-dichloro-2-nitrobenzene
• 4,6-DIBROMO-2,3-DICHLOROANILINE
• 1-BROMO-2,4,5-TRICHLOROBENZENE
• Pigment Green 36
• Bromine