1-tert-butyl-1H-pyrazole-4-carboxylic acid Chemical Properties

Boiling point:

306.2±15.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

3.91±0.10(Predicted)

Appearance

White to off-white Solid

1-tert-butyl-1H-pyrazole-4-carboxylic acid Usage And Synthesis

Synthesis

General procedure for the synthesis of 1-tert-butyl-1H-pyrazole-4-carboxylic acid from ethyl 1-tert-butyl-1H-pyrazole-3-carboxylate: 1. In 8 mL of THF-MeOH-H2O (3:1:1, v/v) mixed solvent, ethyl 1-tert-butyl-1H-pyrazole-3-carboxylate (327 mg, 1.66 mmol) and LiOH (120 mg, 5.0 mmol) were added. 2. The reaction mixture was stirred at 25 °C for 12 hours. 3. After completion of the reaction, H2O and EtOAc were added to the mixture and acidified with 10% HCl solution. 4. The organic layer was separated, dried with Na2SO4 and concentrated under reduced pressure to afford the target product 1-tert-butyl-1H-pyrazole-4-carboxylic acid (217 mg, 78% yield). Mass spectral data: m/z 168.

References

[1] Patent: WO2007/71963, 2007, A2. Location in patent: Page/Page column 59

1-tert-butyl-1H-pyrazole-4-carboxylic acid(950858-65-8)Related Product Information

• RARECHEM AL BE 0987
• RARECHEM AL BF 0987
• RARECHEM AL BI 0987
• 1-tert-butyl-1H-pyrazole-4-carboxylic acid
• ethyl 5-amino-1-tert-butyl-3-cyclobutyl-1H-pyrazole-4-carboxylate
• ETHYL 5-AMINO-1-TERT-BUTYLPYRAZOLE-4-CARBOXYLATE
• 1-TERT-BUTYL-3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
• ethyl 5-amino-1-tert-butyl-3-cyclopentyl-1H-pyrazole-4-carboxylate
• RARECHEM AL BO 2208
• ETHYL 1-(TERT-BUTYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE
• RARECHEM AL BO 2161
• 1-(TERT-BUTYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID