5-BROMO-2-HYDROXY-3-PICOLINE Chemical Properties

Melting point:

170-174 °C(lit.)

Boiling point:

295.1±40.0 °C(Predicted)

Density 

1.5296 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

soluble in Methanol

pka

10.55±0.10(Predicted)

form 

Solid

color 

Off-white

CAS DataBase Reference

89488-30-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-38-41-36/37/38

Safety Statements 

36/37/39-36-26

WGK Germany 

3

Hazard Note 

Harmful

HazardClass 

IRRITANT

HS Code 

29337900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

5-BROMO-2-HYDROXY-3-PICOLINE Usage And Synthesis

Chemical Properties

creamish to light brown crystalline powder

Uses

5-Bromo-3-methylpyridin-2(1H)-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

The general procedure for the synthesis of 5-bromo-3-methylpyridin-2-one from 2-amino-3-methyl-5-bromopyridine is as follows: Example 1. 1A. To a solution of 2.6 M H2SO4 (70 mL) of 2-amino-5-bromo-3-methylpyridine (5.0 g, 26.7 mmol) was added dropwise an aqueous solution (10 mL) of sodium 2-nitrite (5.0 g, 72.5 mmol) at 0 °C. 1B. The reaction mixture was slowly warmed to room temperature and stirring was continued for 1.5 hours. 1C. Upon completion of the reaction, the mixture was filtered and the resulting solid was washed with cold water. 1D. The washed solid was dissolved in dichloromethane (100 mL), dried by adding anhydrous magnesium sulfate, and the solvent was subsequently concentrated to give 5-bromo-3-methylpyridin-2-one (4.2 g, 84% yield). MS (DCI/NH3) m/z: 188/190 (M+H)+.

References

[1] Patent: US2002/19388, 2002, A1
[2] Patent: EP1428824, 2004, A1. Location in patent: Page 49
[3] Patent: WO2008/67644, 2008, A1. Location in patent: Page/Page column 39

5-BROMO-2-HYDROXY-3-PICOLINE(89488-30-2)Related Product Information

• 5-BROMO-2-METHOXY-3-METHYLPYRIDINE
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