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CINCHONINE HYDROCHLORIDE

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CINCHONINE HYDROCHLORIDE Basic information

Product Name:
CINCHONINE HYDROCHLORIDE
Synonyms:
  • (+)-CINCHONINE HYDROCHLORIDE N-HYDRATE
  • CINCHONINE HYDROCHLORIDE N-HYDRATE
  • CINCHODININE DIHYDROCHLORIDE
  • (9S)-Cinchonan-9-ol/hydrochloride,(1:x)
  • Cinchodinine hydrochloride
  • CINCHONINE HYDROCHLORIDE DIHYDRATE R. G.
  • Cinchonidine2HCl
  • (1R)-Quinolin-4-yl((2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol dihydrochloride
CAS:
24302-67-8
MF:
C19H23ClN2O
MW:
330.86
EINECS:
246-139-2
Product Categories:
  • Alkaloids
  • chiral
  • Indole Alkaloids
  • Biochemistry
  • for Resolution of Acids
  • Optical Resolution
  • Synthetic Organic Chemistry
  • Quinoline Alkaloids
  • Quinolinecarboxylic Acids, etc.
  • Quinolines
Mol File:
24302-67-8.mol
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CINCHONINE HYDROCHLORIDE Chemical Properties

Melting point:
179 °C
refractive index 
-78 ° (C=1, EtOH)
storage temp. 
2-8°C, stored under nitrogen
form 
powder to crystal
color 
White to Almost white
Water Solubility 
very faint turbidity
Merck 
1455
CAS DataBase Reference
24302-67-8(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
HS Code 
29339900
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CINCHONINE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

Off-white powder

Synthesis

About 80% of the solvent volume was distilled at atmospheric pressure. Ethyl acetate (190 ml) was added and the organic solution was washed with aqueous HCl (2M, 114 ml) to give an ethyl acetate solution of (XV). The ethyl acetate solution of (XV) was added to an acetonitrile (760 ml) suspension of cinchonidine (55.94 g, 0.19 mol) at 60??C. The resulting mixture was stirred at 60 ??C for 10 min, then cooled to 22 ??C and filtered. The solid was recrystallized from isopropanol (1500 ml) and dried to give 24.8 g (29% yield) of white solid cinchonidine dihydrochloride.

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