PROSTAGLANDIN H1 Chemical Properties

Boiling point:

486.2±38.0 °C(Predicted)

Density 

1.113±0.06 g/cm3(Predicted)

Flash point:

-17 °C

storage temp. 

−70°C

solubility 

Ethanol: >100 mg/ml; PBS pH 7.2: >2 mg/ml

form 

acetone solution

pka

4.78±0.10(Predicted)

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

11-36-66-67

Safety Statements 

9-16-26

RIDADR 

UN 1090 3/PG 2

WGK Germany 

1

MSDS

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PROSTAGLANDIN H1 Usage And Synthesis

Description

Prostaglandin H1 (PGH1) is the unstable precursor to all 1-series PGs and thromboxanes.1,2,3 It is produced from dihomo-γ-linolenic acid (DGLA; Item No. 90230) by COX-1 and COX-2. 4,2 PGH1 is an agonist of the PGD2 receptor CRTH2.5 It increases intracellular calcium levels in HEK293 cells expressing CRTH2 when used at a concentration of 3 µM and induces CRTH2 internalization at 1 µM, an effect that can be blocked by the CRTH2 antagonist TM30089 (CAY10471; Item No. 10006735). PGH1 is also a suicide inhibitor of platelet thromboxane synthase (Ki = 28 µM).6WARNING This product is not for human or veterinary use.

Definition

ChEBI: Prostaglandin H1 is a member of the class of prostaglandins H that is prostaglandin H2 lacking the double bond at position 5. It has a role as a human xenobiotic metabolite. It is a prostaglandins H, an oxylipin, a bridged compound, an olefinic compound, an organic peroxide and a secondary alcohol. It is a conjugate acid of a prostaglandin H1(1-).

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