4-Fluorobenzyl chloride Chemical Properties

Melting point:

-18 °C

Boiling point:

82 °C26 mm Hg(lit.)

Density 

1.207 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.513(lit.)

Flash point:

141 °F

storage temp. 

Store below +30°C.

solubility 

Chloroform (Slightly), Hexanes (Slightly)

form 

Powder or Crystals

Specific Gravity

1.207

color 

Yellow

explosive limit

1.30%(V)

Water Solubility 

417mg/L(temperature not stated)

Sensitive 

Lachrymatory

BRN 

742272

InChI

1S/C7H6ClF/c8-5-6-1-3-7(9)4-2-6/h1-4H,5H2

InChIKey

IZXWCDITFDNEBY-UHFFFAOYSA-N

SMILES

Fc1ccc(CCl)cc1

CAS DataBase Reference

352-11-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-(chloromethyl)-4-fluoro-(352-11-4)

EPA Substance Registry System

Benzene, 1-(chloromethyl)-4-fluoro- (352-11-4)

Safety Information

Hazard Codes 

C

Risk Statements 

34-22

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2920 8/PG 2

WGK Germany 

2

F 

19

Hazard Note 

Corrosive/Lachrymatory

TSCA 

TSCA listed

HazardClass 

8

PackingGroup 

III

HS Code 

29036990

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Skin Corr. 1B

MSDS

• Language:English Provider:alpha-Chloro-p-fluorotoluene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Fluorobenzyl chloride Usage And Synthesis

Chemical Properties

clear colorless to slightly yellow liquid

Uses

p-Fluorobenzyl Chloride is a chemical intermediate in the synthesis of various pharmaceutical and agricultural goods.

Synthesis

Photocatalyst: nanosilver/silver chloride surface plasma composite;
Substrate: p-fluorotoluene; Halogenator: potassium chloride;
(1) 50 ml of water, 7 g of sodium chloride and 2.5 ml of hydrochloric acid (mass fraction 35%) were added in a photocatalytic reactor, respectively, and dissolved with stirring;
(2) then add 0.3 g of nanosilver/silver chloride as a photocatalyst (nanosilver loading 8.5 mol%) and 0.05 g of tetrabutylammonium chloride as a phase-transfer catalyst, and finally add 15 ml of p-fluorotoluene; the loading is the molar amount of nanoprecious metals as a molar percentage of the total amount of nanoprecious metal/semiconductor surface plasmonic composite.
(3) Under strong magnetic stirring, then turn on 300W xenon lamp irradiation, and react for 5h at room temperature;
(4) Filtering to recover the catalyst, separating out the organic phase and recycling the aqueous phase for reuse. Samples were analyzed by GS, the conversion rate of p-fluorotoluene was 36%, and no polychlorinated products were detected. Distillation to collect 180.5-182 ?? fraction, got 4-fluorobenzyl chloride, yield 89%.

4-Fluorobenzyl chloride(352-11-4)Related Product Information

• 4-Fluoronitrobenzene
• 4-Fluorophenoxyacetic acid
• Methyl 4-fluorobenzoate
• Ethyl 4-fluorobenzoate
• 4-Fluorobenzoic acid
• 4-Fluorobenzonitrile
• 4-Fluorophenylacetic acid
• 4-Bromofluorobenzene
• 3,4-Difluorobenzoyl chloride
• 4-Fluorobenzoyl chloride
• 3,4,5-TRIFLUOROBENZOYL CHLORIDE
• 2,3,4-TRIFLUOROBENZOYL CHLORIDE
• 4-FLUOROBENZAL CHLORIDE
• 4-FLUORO-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• Pentafluorobenzyl chloride
• 2,4-Difluorobenzyl chloride
• 4,4'-Difluorodiphenylmethylchloride
• 2,4,6-TRIFLUOROBENZOYL CHLORIDE