Picotamide
Picotamide Basic information
- Product Name:
- Picotamide
- Synonyms:
-
- 4-METHOXY-N,N'-BIS(3-PYRIDINYLMETHYL)-1,3-BENZENEDICARBOXAMIDE
- PICOTAMIDE
- 4-methoxy-n,n’-bis(3-pyridylmethyl)-isophthalamid
- 4-methoxy-n,n’-bis(3-pyridylmethyl)isophthalamide
- g137
- n,n’-bis(3-picolyl)-4-methoxyisophthalamide
- n,n’-bis(3-pyridinylmethyl)-4-methoxy-1,3-benzenedicarboxamide
- n,n’-bis(3-pyridinylmethyl)-4-methoxy-3-benzenedicarboxamide
- CAS:
- 32828-81-2
- MF:
- C21H20N4O3
- MW:
- 376.41
- EINECS:
- 251-245-7
- Mol File:
- 32828-81-2.mol
Picotamide Chemical Properties
- Melting point:
- 128-131℃
- Boiling point:
- 668.1±55.0 °C(Predicted)
- Density
- 1.246±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
- pka
- 13.31±0.46(Predicted)
- form
- White solid.
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
MSDS
- Language:English Provider:4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
Picotamide Usage And Synthesis
Description
Picotamide is an unique antithrombotic agent which acts by selectively inhibiting thromboxane synthesis and blocking platelet thromboxane receptors without affecting prostaglandin synthesis. It is reported to be useful in the treatment of myocardial infarction, cerebrovascular disorders, pulmonary embolism and atherosclerosis.
Originator
Manetti-Roberts (Beecham (Italy)
Uses
Picotamide is a dual inhibitor of thromboxane A2 and thromboxane A2 synthase. It is used in aptamers for targeting coagulation factor XIII and there used for treatment of thrombosis.
Uses
Keratolytic.
Definition
ChEBI: 4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide is a member of benzamides.
brand name
Plactidil
References
Modesti, et al. (1989), Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide; Eur. J. Pharmacol.. 169 85 Modesti, et al. (1991), Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 inhibitor; Br. J. Pharmacol.. 31 439 Ratti et al. (1998), Picotamide, an antithromboxane agent. Inhibits the migration and proliferation of arterial myocytes; Eur. J. Pharmacol. 355 77
PicotamideSupplier
- Tel
- 1-(800)-881-8210
- inquiries@lgmpharma.com
- Tel
- 0086-21-58956006
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Tel
- 021-33632979
- info@tsbiochem.com
- Tel
- 021-65675885 18964387627
- info@efebio.com
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