1-Bromoethyl acetate Chemical Properties

Boiling point:

122-125 °C(Press: 738 Torr)

Density 

1.48

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Sparingly), Methanol (Sparingly)

form 

Oil

color 

Colourless to Dark Brown

Stability:

Hygroscopic

InChI

InChI=1S/C4H7BrO2/c1-3(5)7-4(2)6/h3H,1-2H3

InChIKey

IIASCQBFNHWZBE-UHFFFAOYSA-N

SMILES

C(OC(=O)C)(Br)C

Safety Information

Safety Statements 

24/25

HS Code 

29153900

1-Bromoethyl acetate Usage And Synthesis

Chemical Properties

Pale Yellow Oil

Uses

1-Bromoethyl Acetate is a 1-haloalkyl ester that is used in the modification of of antibiotics. It is an intermediate that can be usefully used in the preparation of the oral antibiotic Cefuroxime axetil. 

Synthesis

1-bromoethyl acetate is prepared by reacting acetyl bromide and acetaldehyde using zinc chloride as a catalyst. 
After cooling 30 ml of hydrogen bromide / acetic acid (1.2 equiv) to 0 ° C., 53.5 ml (1.0 equiv) of vinyl acetate was slowly added thereto, followed by stirring for 1 hour. It was extracted with dichloromethane, washed with distilled water at 0-5 ° C., dehydrated with anhydrous magnesium sulfate, and distilled under reduced pressure to obtain 81.4 g of 1-bromoethyl acetate.

1-Bromoethyl acetate(40258-78-4)Related Product Information

• Tocopheryl acetate
• tert-Butyl bromoacetate
• Allyl bromide
• Ethyl acetate
• Ethyl bromoacetate
• Ethyl bromodifluoroacetate
• Bromoacetic acid
• Sodium bromate
• Methyl acetate
• POLY(VINYL ACETATE)
• Sodium acetate
• Benzyl bromide
• Vinyl acetate
• Triacetin
• Ethidium bromide
• Glatiramer acetate
• Rocuronium bromide
• Methyl bromoacetate