5-CHLORO-2-FORMYLPYRIDINE Chemical Properties

Melting point:

66-68°

Boiling point:

208℃

Density 

1.332

Flash point:

79℃

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

1.44±0.10(Predicted)

color 

White to Yellow to Orange

InChI

InChI=1S/C6H4ClNO/c7-5-1-2-6(4-9)8-3-5/h1-4H

InChIKey

YYLBDBOSXXSZQQ-UHFFFAOYSA-N

SMILES

C1(C=O)=NC=C(Cl)C=C1

Safety Information

Hazard Codes 

Xi

Risk Statements 

36-43

Safety Statements 

26-36/37

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

5-CHLORO-2-FORMYLPYRIDINE Usage And Synthesis

Synthesis

Ethyl 5-chloropyridine-2-carboxylate (146 mg, 76% yield) was obtained by reacting 5-chloropyridine-2-carboxylic acid (200 mg, 1.03 mmol) in ethanol (3 mL) and a dioxane solution (0.5 mL) of 4M HCl at 90 °C for 20 hours. Subsequently, ethyl 5-chloropyridine-2-carboxylate (146 mg, 0.786 mmol) was dissolved in dichloromethane (4.0 mL), to which a toluene solution of 1M DIBAL (1.74 mL, 1.74 mmol) was added and reacted for 20 min to give 5-chloropyridine-2-carbaldehyde (58 mg, 52% yield). The product was analyzed by GC-MS and the molecular ion peak (M+) was 141.

References

[1] Patent: WO2004/14902, 2004, A2. Location in patent: Page 42

5-CHLORO-2-FORMYLPYRIDINE(31181-89-2)Related Product Information

• 5-chloropyrazine-2-carboxamide
• Pyrazinecarboxylic acid, 5-chloro-, ethyl ester
• 5-CHLORO-PYRIDINE-3-CARBALDEHYDE
• diMethyl 5-chloropyridine-2,3-dicarboxylate
• ETHYL 5-CHLOROPYRIDINE-2-CARBOXYLATE
• 5-CHLOROPYRIDO[4,3-B]PYRAZINE
• 3-CHLORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
• 5-Chloropyrazolo[1,5-a]pyrimidine
• 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile
• 5-CHLOROPYRIDINE-2-BORONIC ACID PINACOL ESTER
• 5-Chloropyridine-2-carboxamide
• LAZABEMIDE
• PICLORAM METHYL ESTER
• Picloram
• Tetrachloropyridine-2-carboxylic acid
• 3,4,5-Trichloropyridine-2-carboxylic acid
• 2-Chloropyridine-3-carboxaldehyde, 2-Chloro-3-formylpyridine,2-CHLORO-3-FORMYLPYRIDINE
• 2,6-Dichloropyridine-4-carboxaldehyde