4,4-Diethoxy-N,N-dimethyl-1-butanamine Chemical Properties

Boiling point:

194-195C

Density 

0.844 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.421(lit.)

Flash point:

158 °F

storage temp. 

2-8°C

solubility 

Chloroform, Ethyl Acetate

form 

Oil

pka

9.71±0.28(Predicted)

color 

Colourless to Pale Yellow

CAS DataBase Reference

1116-77-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

41-34-10-36/37/38

Safety Statements 

26-36/37/39-16-37

RIDADR 

UN 3267 8 / PGIII

WGK Germany 

3

HS Code 

29225090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4,4-Diethoxy-N,N-dimethyl-1-butanamine Usage And Synthesis

Chemical Properties

Light yellow liquid

Uses

4,4-Diethoxy-N,N-dimethyl-1-butanamine is used in organic synthesis and pharmaceutical intermediates, it is an intermediate for Sumatriptan, Rizatriptan, Almotriptan, Zolmitriptan.

Application

4-Dimethylaminobutyraldehyde Diethyl Acetal (Zolmitriptan USP Related Compound H) is used in the preparation of N,N-Dimethyltryptamines, 5-HT1D receptor agonists, for medicinal treatments such as antimigraine drugs.

Preparation

4-Dimethylaminobutyraldehyde diethyl acetal synthesis: The reaction of 1-bromo-3-chloro propane and dimethylamine solution with PEG as a phase transfer catalyst, and obtained 3-dimethylamino-1-chloro propane. 3-dimethylamino-1-chloro propane reacted with magnesium and Grinard reagent was acquired. 4-Dimethylaminobutyraldehyde diethyl acetal is obtained by the reaction of Grinard reagent and triethyl orthoformate. The yield was 70.11%.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 2401, 1994 DOI: 10.1016/0040-4039(94)85230-8

4,4-Diethoxy-N,N-dimethyl-1-butanamine(1116-77-4)Related Product Information

• 2,2-Diethoxyethylamine
• Bromoacetaldehyde diethyl acetal
• Diethyl malonate
• Dacthal
• Dimethyl carbonate
• Dimethyl sulfate
• Ethylene glycol diethyl ether
• ETHANE
• Diethyl oxalate
• Dimethyl ether
• Dimethyl fumarate
• POLY(VINYL BUTYRAL)
• Mefenpyr-diethyl
• N,N-Dimethylformamide
• Dimethyl disulfide
• Acetal
• Metformin
• Dimethyl phthalate