Sodium propylparaben Chemical Properties

Melting point:

302°C

Density 

1.24 g/cm3 (25 °C)

vapor pressure 

0.001Pa at 20℃

storage temp. 

Store at +15°C to +25°C.

solubility 

Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

form 

Solid

pka

8.46[at 20 ℃]

color 

White to Off-White

PH

9.5-10.5 (1g/l, H2O, 20°C)

Water Solubility 

1000g/L at 23℃

Stability:

Hygroscopic

LogP

0.27 at 23℃

CAS DataBase Reference

35285-69-9(CAS DataBase Reference)

EPA Substance Registry System

Propylparaben sodium (35285-69-9)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

2

RTECS 

DH2850000

HS Code 

2918 29 00

Toxicity

LD50 orally in Rabbit: > 5000 mg/kg

MSDS

• Language:English Provider:SigmaAldrich

Sodium propylparaben Usage And Synthesis

Chemical Properties

White or almost white, hygroscopic, crystalline powder.

Chemical Properties

Propylparaben sodium occurs as a white, crystalline, odorless or almost odorless powder.

Uses

Pharmaceutic aid (antimicrobial preservative).

Uses

Sodium Propylparaben is a preservative. Sodium Propylparaben is also an excipient used in various pharmaceutical formulations.

Production Methods

Propylparaben sodium is produced from benzoic acid.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Propylparaben sodium is used as an antimicrobial or antifungal preservative in oral pharmaceuticals and in many water-based cosmetics. It is generally used in combination with other paraben esters.

Contact allergens

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Safety

Propylparaben sodium is used in oral pharmaceuticals and cosmetics. The pure form is toxic by the IV route and moderately toxic by ingestion and the IP route. Propylparaben sodium may cause asthma, rashes, and hyperactivity.
LD50 (mouse, IP): 0.49 g/kg
LD50 (mouse, IV): 0.18 g/kg
LD50 (mouse, oral): 3.7 g/kg

storage

Propylparaben sodium is stable under normal conditions. It decomposes on heating. Store in a tightly closed container.

Incompatibilities

The activity of propylparaben sodium can be adversely affected by the presence of other excipients or active ingredients, such as atropine, essential oils, iron, magnesium trisilicate, talc, polysorbate 80 and other nonionic surfactants, sorbitol, weak alkalis, and strong acids.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, tablets, suspensions). Accepted for use as a food additive in Europe. Included in nonparenteral medicines (oral capsules, mixtures, orodispersible tablets, solutions and suspensions; cutaneous emulsions) licensed in the UK.

Sodium propylparaben(35285-69-9)Related Product Information

• Sodium methylparaben
• p-Hydroxybenzoic acid ethyl ester sodium salt
• Ethylparaben
• Propylparaben
• Methyl 3-(4-hydroxyphenyl)propionate
• Methyl 4-hydroxyphenylacetate
• L(+)-Arginine
• Monomethyl fumarate
• Disodium stannous citrate
• Ribavirin
• POLOXAMER124
• Methylparaben
• Butylparaben
• 4-Hydroxycinnamic acid
• 4-(Hydroxymethyl)phenoxyacetic acid
• Methyl 4-cyanobenzoate
• Ethyl 4-cyanobenzoate
• 4-Hydroxybenzoic acid