1-Naphthyl isocyanate Chemical Properties

Melting point:

4 °C (lit.)

Boiling point:

267 °C/761 mmHg (lit.)

Density 

1.177 g/mL at 25 °C (lit.)

vapor density 

2.9 (vs air)

vapor pressure 

168.8 mm Hg ( 37.7 °C)

refractive index 

n20/D 1.6344(lit.)

Flash point:

-1 °F

storage temp. 

Inert atmosphere,2-8°C

solubility 

Miscible with alcohol, chloroform and diethyl ether.

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Sensitive 

Moisture Sensitive

Merck 

14,6410

BRN 

742779

Stability:

Stable. Incompatible with strong oxidizing agents, alcohols.

CAS DataBase Reference

86-84-0(CAS DataBase Reference)

NIST Chemistry Reference

Naphthalene, 1-isocyanato-(86-84-0)

EPA Substance Registry System

1-Isocyanatonaphthalene (86-84-0)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38-42

Safety Statements 

9-16-25-33-60-61-62-36/37/39-26-45-27-23

RIDADR 

UN 2206 6.1/PG 3

WGK Germany 

3

RTECS 

GU6300000

F 

3-10

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29291090

MSDS

• Language:English Provider:1-Isocyanatonaphthalene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Naphthyl isocyanate Usage And Synthesis

Chemical Properties

colourless or slightly yellow liquid

Uses

1-Naphthyl isocyanate is used in the preparation of cationic aromatic urethane. It is useful for the study of cholangiolitic hepatotoxicity in laboratory animals. It is also employed as separate enantiomers of beta-blockers.

Synthesis Reference(s)

Synthetic Communications, 23, p. 335, 1993 DOI: 10.1080/00397919308009785

Purification Methods

Distil the isocyanate at atmospheric pressure or in a vacuum. It can be crystallised from pet ether (b 60-70o) at low temperature. It has a pungent odour, is TOXIC and is absorbed through the skin. [Beilstein 12 H 1244, 12 III 2948.]

1-Naphthyl isocyanate(86-84-0)Related Product Information

• 2-BROMOPHENYL ISOCYANATE
• BENZENESULFONYL ISOCYANATE
• 2,6-Dimethylphenyl isocyanate
• 4-ETHYLPHENYL ISOCYANATE
• 2-BIPHENYLYL ISOCYANATE
• Nitronaphthalene
• Cyanamide
• NAPHTHENE
• 2,7-Dihydroxy-Naphthene
• 2-Naphthene,2-NAPHTHENE BORONIC ACID, NAPHTHALENE-2-BORONIC ACID, 2-NAPHTHYLBORONIC ACID
• beta-Methoxy Naphthene
• hexahydroxy-benzene
• 1,5-DIHYDROXY NAPHTHENE
• 1-(Chloromethyl)naphthene
• NAPHTHENE
• Chlorosulfonyl isocyanate
• Propyl isocyanate
• 4-Chlorophenyl isocyanate