Artemifone
Artemifone Basic information
- Product Name:
- Artemifone
- Synonyms:
-
- Artemifone
- 10alpha-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-deoxodihydroartemisinin
- Artemisone
- BAY 44-9585
- YHVQDGXHTCSGBJ-AKSSTEKGSA-N
- 4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]thiomorpholine 1,1-dioxide
- Thiomorpholine, 4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]-, 1,1-dioxide
- Cytomegalovirus,Inhibitor,Parasite,CMV,inhibit,Artemisone
- CAS:
- 255730-18-8
- MF:
- C19H31NO6S
- MW:
- 401.52
- Mol File:
- 255730-18-8.mol
Artemifone Chemical Properties
- Boiling point:
- 536.5±50.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 130 mg/mL (323.77 mM)
- form
- Solid
- pka
- 2.99±0.20(Predicted)
- color
- White to off-white
Artemifone Usage And Synthesis
Uses
Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC50 of 0.83 nM[1]. Artemisone is also a potent inhibitor of human CMV[2].
in vivo
Artemisone is effectve at inhibiting the parasitaemia in the P. berghei NY susceptible strain, with an ED50 of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration[1].
Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line P. yoelii NS[1]
IC 50
Plasmodium
References
[1] Vivas L, et al. Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo. J Antimicrob Chemother. 2007 Apr;59(4):658-65. DOI:10.1093/jac/dkl563
[2] Ruiyuan Cao, et al. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro. ACS Infect. Dis. 2020 Jul.
ArtemifoneSupplier
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Tel
- 18939837085
- youchemicals@gmail.com
- Tel
- 021-65675885 18964387627
- info@efebio.com
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Tel
- 010-60605840 18892239720
- psaitong@jm-bio.com