GSK-CXCR2
GSK-CXCR2 Basic information
- Product Name:
- GSK-CXCR2
- Synonyms:
-
- GSK-CXCR2
- N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea
- SB 265610
- 1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea
- Urea, N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-
- SB265610 >=98% (HPLC)
- CXCR,nonpeptide,inhibit,Inhibitor,SB-265610,inflammation,recruitment,Delay,SB 265610,healing,neutrophil,SB265610,wound,CXC chemokine receptors
- CAS:
- 211096-49-0
- MF:
- C14H9BrN6O
- MW:
- 357.16
- Mol File:
- 211096-49-0.mol
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GSK-CXCR2 Chemical Properties
- Boiling point:
- 527.0±45.0 °C(Predicted)
- Density
- 1.77±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- pka
- 6.13±0.40(Predicted)
- color
- white to light brown
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GSK-CXCR2 Usage And Synthesis
Uses
SB 265610 is an anti-tumor pharmaceutical developed to act as an antagonist to cysteine-amino acid-cysteine (CXC) chemokines receptor 2 antagonist.
Biological Activity
Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca 2+ mobilization (IC 50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo .
Biochem/physiol Actions
SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.
storage
Store at RT
GSK-CXCR2Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
AdooQ Bioscience CHINA
- Tel
- 025-58849295 18951903616;
- info@adooq.cn
Sigma-Aldrich
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- 021-61415566 800-8193336
- orderCN@merckgroup.com
Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
- info@efebio.com