Triclocarban Chemical Properties

Melting point:

254-256 °C (lit.)

Boiling point:

344.2±42.0 °C(Predicted)

Density 

1.5732 (rough estimate)

vapor pressure 

<0.1 mm Hg ( 25 °C)

refractive index 

1.6300 (estimate)

Flash point:

150 °C

storage temp. 

Sealed in dry,Room Temperature

solubility 

methanol: soluble

pka

12.77±0.70(Predicted)

form 

Solid

color 

Fine plates

Water Solubility 

<0.1 g/100 mL at 26 ºC

Merck 

14,9654

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents strong bases.

InChIKey

ICUTUKXCWQYESQ-UHFFFAOYSA-N

LogP

3.633 at 25℃

CAS DataBase Reference

101-20-2(CAS DataBase Reference)

NIST Chemistry Reference

3,4,4'-Trichloro carbanilide(101-20-2)

EPA Substance Registry System

Triclocarban (101-20-2)

Safety Information

Hazard Codes 

N

Risk Statements 

50/53

Safety Statements 

60-61

RIDADR 

UN 3077 9/PG 3

WGK Germany 

2

RTECS 

FE1250000

HazardClass 

9

PackingGroup 

III

HS Code 

38220090

Hazardous Substances Data

101-20-2(Hazardous Substances Data)

Toxicity

LD50 ipr-mus: 2100 mg/kg LPPTAK 27,306,79

MSDS

• Language:English Provider:N-(3,4-Dichlorophenyl)-N'-(4-chlorophenyl)urea
• Language:English Provider:SigmaAldrich

Triclocarban Usage And Synthesis

Chemical Properties

white crystals or powder

Originator

Cutisan,Innothera,France,1960

Uses

Labelled Triclocarban

Uses

Used as bacteriostat and antiseptic in soaps and other cleansing compositions. Antiseptic, disinfectant.

Definition

ChEBI: A member of the class of ureas that is urea substituted by a 4-chlorophenyl and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.

Manufacturing Process

To a suitable reaction vessel equipped with a thermometer, agitator and reflux condenser and containing 8.1 parts by weight (substantially 0.05 mol) of 3,4-dichloroaniline in approximately 57 parts by weight of diethyl ether is added dropwise a solution of 7.7 parts by weight (substantially 0.05 mol) of 4- chlorophenyl isocyanate in approximately 15 parts by weight of diethyl ether at such a rate so as to maintain gentle reflux. Upon completion of the isocyanate addition the reaction mass is agitated for about one hour. The mass is filtered and the residue washed with diethyl ether. The dried product is a white fluffy solid which on recrystallization from ethanol gives fine white plates of 4,3',4'-trichlorocarbanilide, melting point 255.2°C to 256.0°C (88.0% yield)

Therapeutic Function

Disinfectant

General Description

Fine white plates or white powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

The flash point of Triclocarban has not been determined. Triclocarban is, however, probably combustible.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

3,4,4′-Trichlorocarbanilide interferes with mammalian reproduction and can cause methemoglobinemia in humans.

Safety Profile

Moderately toxic byintraperitoneal route. When heated to decomposition itemits very toxic fumes of Clí and NOx.

Triclocarban(101-20-2)Related Product Information

• Triclosan
• Trichloroethylene
• Trichlorosilane
• UREA-13C
• Trichloroisocyanuric acid
• Sucralose
• Trichloroacetic acid
• CERIUM(III) CHLORIDE
• NEODYMIUM CHLORIDE
• Phosphorus oxychloride
• Trichloroacetonitrile
• Aluminum chloride
• Trichloroacetyl chloride
• Chlorobutanol
• VANADIUM(V) TRICHLORIDE OXIDE
• 4-Chlorophenylurea
• Chloroform
• UREA HYDROCHLORIDE