1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE Basic information
- Product Name:
- 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
- Synonyms:
-
- SKF 89976A HYDROCHLORIDE
- 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
- SKF89976AHCl
- skf-89976a
- 1-(4,4-Diphenyl-3-buten-1-yl)-3-piperidinecarboxylic acid hydrochloride
- 1-(4,4-Diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride
- l-SKF89976A hydrochloride
- d,l-SKF89976A hydrochloride
- CAS:
- 85375-15-1
- MF:
- C22H26ClNO2
- MW:
- 371.9
- Product Categories:
-
- GABA/Glycine receptor
- GABA
- Mol File:
- 85375-15-1.mol
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1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE Chemical Properties
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO: 20 mg/mL, soluble
- form
- solid
- color
- white
MSDS
- Language:English Provider:SigmaAldrich
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1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE Usage And Synthesis
Uses
SKF-89976A is a GABA transporters (GATs) type 1 inhibitor.
Biological Activity
A potent GABA uptake inhibitor, selective for GAT-1 (IC 50 values are 0.13, 550, 944 and 7210 μ M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (K i = 7 μ M) and transmitter-gated current non-competitively (K i = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo .
storage
+4°C (desiccate)
1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDESupplier
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