N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea
N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea Basic information
- Product Name:
- N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea
- Synonyms:
-
- N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea
- Diflapolin
- Urea, N-[4-(2-benzothiazolylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)-
- 1-(4-(Benzo[d]thiazol-2-ylmethoxy)-2-methylphenyl)-3-(3,4-dichlorophenyl)urea
- N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea ISO 9001：2015 REACH
- diseases,Inhibitor,permeability,neutrophil,Epoxide Hydrolase,Diflapolin,vascular,FLAP,infiltration,5-LO activating protein,inflammation,cysteinyl-LTs,inhibit
- Diflapolin, 10 mM in DMSO
- CAS:
- 724453-98-9
- MF:
- C22H17Cl2N3O2S
- MW:
- 458.36
- Mol File:
- 724453-98-9.mol
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N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO:42.0(Max Conc. mg/mL);91.63(Max Conc. mM)
- form
- A crystalline solid
- color
- White to off-white
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N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea Usage And Synthesis
Uses
Synthesis and structure-activity relationships of Diflapolin analogs as dual sol. Epoxide Hydrolase /5-Lipoxygenase-activating protein inhibitors.FLAP inhibitor.
in vivo
Diflapolin (1-10 mg/kg; i.p.; 30?min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments[1].
| Animal Model: | Male CD-1 mice (zymosan-induced peritonitis mouse model)[1] |
| Dosage: | 1, 3 and 10?mg/kg |
| Administration: | I.p.; 30?min before zymosan injection |
| Result: | Induced a significant reduction of LTC4 and LTB4 peritoneal levels, starting from the dose of 1?mg/kg and comparable to the effect of MK886. |
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