Hydrocortisone acetate Chemical Properties

Melting point:

223 °C (dec.)(lit.)

Boiling point:

446.1°C (rough estimate)

alpha 

D25 +166° (c = 0.4 in dioxane); D25 +150.7° (c = 0.5 in acetone)

Density 

d420 1.289

refractive index 

1.4593 (estimate)

Flash point:

223°C

storage temp. 

0-6°C

solubility 

Practically insoluble in water, slightly soluble in anhydrous ethanol and in methylene chloride

pka

12.42±0.70(Predicted)

form 

Solid

color 

White to Off-White

Water Solubility 

Insoluble in water.

Decomposition 

223 ºC

Merck 

14,4787

BRN 

2066841

Stability:

Stable, but may be light or moisture sensitive. Incompatible with strong oxidizing agents.

LogP

2.190

CAS DataBase Reference

50-03-3(CAS DataBase Reference)

NIST Chemistry Reference

Hydrocortisone acetate(50-03-3)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

63-10-45

Safety Statements 

36/37-45-53

WGK Germany 

3

RTECS 

GM8960000

HS Code 

29372100

Toxicity

LD50 intraperitoneal in mouse: 2300mg/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Hydrocortisone acetate Usage And Synthesis

Adrenocorticotropic hormone drugs

Hydrocortisone acetate is an adrenal hormone drugs, white crystalline powder, odorless, bitter taste. The melting point is 216~222 ℃, right optical. Slightly soluble in ethanol, ether, chloroform, acetone, insoluble in water. It was synthesized by In 17α-hydroxy progesterone.
Hydrocortisone acetate has important physiological activities such as anti-inflammatory, anti-viral, anti-allergic, anti-shock, reducing inflammatory exudation effect, commonly used in clinical adrenal insufficiency and autoimmune diseases. Preparations are injection, tablets, ointments and eye drops. Adding a small amount of hydrocortisone acetate in some cosmetics cortisol can increase the efficacy of anti-allergy and improve the degree of whitening of the skin, but long-term using of such substances can cause the skin produce hormone-dependent disease. Our cosmetics cosmetics specifications prescribedthathormone substances can not be added.

Indications

For allergic, non-infectious skin diseases and a number of proliferative skin disorders. Such as dermatitis, eczema, neurodermatitis, seborrheic dermatitis and itching psychosis.

Figure 1 the chemical structure formula of tetra-fluoroethane.

Contraindications

1. This medicine and matrix components allergy and allergic to other glucocorticoids are prohibited.
2. The primary bacterial, fungal and viral infectious skin diseases such as disabledare prohibited.
The above information is edited by the chemicalbook of KuiMing.

Adverse Reactions

Long-term using can cause local skin atrophy, telangiectasia, pigmentation, folliculitis, perioral dermatitis and secondary infection.

Precautions

1. Not long-term, large-scale use.
2. The coated parts such as a burning sensation, itching, swelling, etc., should stop the medication.

Chemical Property

White or almost white crystalline powder, odorless. Mp218-221.5 ℃; 25D + 166 ° (dioxane) Specific rotation [α]; ethanol maximum absorption at 240nm wavelength. Insoluble in water, slightly soluble in ethanol (1: 230) and chloroform (1: 150), insoluble in ether.

Uses

Corticosteroid drugs, have anti-inflammatory, anti-allergic, anti-toxins, anti-shock effect.

Production methods

Hydrocortisone and acetic anhydride in pyridine esterification.

Chemical Properties

white powder

Uses

Glucocorticoid

Uses

Hydrocortisone acetate is used to treat hemorrhoids and itching/swelling in the rectum and anus. It is used to treat certain intestinal problems (such as ulcerative colitis of the rectum and other rectal/anal inflammatory conditions).

Definition

ChEBI: Cortisol 21-acetate is a tertiary alpha-hydroxy ketone and a cortisol ester.

brand name

Cortef Acetate (Pharmacia & Upjohn); Cortifoam (Schwarz Pharma); Cortril (Pfizer); Dricort (Ingram); Hydrocortone (Merck).

Clinical Use

Corticosteroid:

Local inflammation of joints and soft tissue

Drug interactions

Potentially hazardous interactions with other drugs
Aldesleukin: avoid concomitant use.
Antibacterials: metabolism accelerated by rifampicin; metabolism possibly inhibited by erythromycin; concentration of isoniazid possibly reduced.
Anticoagulants: efficacy of coumarins and phenindione may be altered.
Antiepileptics: metabolism accelerated by carbamazepine, phenobarbital, fosphenytoin, phenytoin and primidone.
Antifungals: increased risk of hypokalaemia with amphotericin - avoid; metabolism possibly inhibited by itraconazole and ketoconazole.
Antivirals: concentration possibly increased by ritonavir.
Ciclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroids
. Cobicistat: concentration of hydrocortisone possibly increased - increased risk of adrenal suppression.
Diuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diuretics.
Vaccines: high dose corticosteroids can impair immune response to vaccines - avoid concomitant use with live vaccines.

Metabolism

Hydrocortisone is metabolised in the liver and most body tissues to hydrogenated and degraded forms such as tetrahydrocortisone and tetrahydrocortisol. These are excreted in the urine, mainly conjugated as glucuronides, with a very small proportion of unchanged hydrocortisone.

Purification Methods

The acetate recrystallises from Me2CO/Et2O or aqueous Me2CO as hygroscopic monoclinic crystals. UV has max at 242 nm (A1cm 1% 390) in MeOH. Its solubility at 25o is: H2O (0.001%), EtOH (0.45%), MeOH (0.04%), Me2CO (1.1%), CHCl3 (0.5%), Et2O (0.15%), and it is very soluble in Me2NCHO. [Wendler et al. J Am Chem Soc 74 3630 1952; Antonucci et al. J Org Chem 18 7081 1953, Beilstein 8 IV 3424.]

Hydrocortisone acetate(50-03-3)Related Product Information

• Hydrocortisone
• Hydrocortisone-17-butyrate
• Sodium acetate
• Glatiramer acetate
• Ethyl acetate
• Ammonium acetate
• POLY(VINYL ACETATE)
• Hydrocortisone sodium succinate
• Vinyl acetate
• Cellulose acetate
• Hydrocortisone Butyrate Propionate
• Hydrocortisone 21-hemisuccinate
• Amebucort
• Hydrocortisone
• hydrocortamate
• ACETATE
• 4-PREGNENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-CAPRYLATE
• HYDROCORTISONE CYPIONATE (200 MG)