Homovanillic acid
Homovanillic acid Basic information
- Product Name:
- Homovanillic acid
- Synonyms:
-
- 4-Hydroxy-3-methoxybenzeneacetic acid
- 4-hydroxy-3-methoxy-benzeneaceticaci
- 4-hydroxy-3-methoxy-Benzeneaceticacid
- Acetic acid, (4-hydroxy-3-methoxyphenyl)-
- Homovanilic acid
- Homovanillinic acid
- Vanilacetic acid
- Vanillacetic Acid
- CAS:
- 306-08-1
- MF:
- C9H10O4
- MW:
- 182.17
- EINECS:
- 206-176-7
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- Multisubstituted Benzene
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Pharmaceutical Intermediates
- Aromatics
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Mol File:
- 306-08-1.mol
Homovanillic acid Chemical Properties
- Melting point:
- 142-145 °C(lit.)
- Boiling point:
- 235.56°C (rough estimate)
- Density
- 1.1634 (rough estimate)
- refractive index
- 1.4209 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- 4.39±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to beige
- Water Solubility
- soluble
- Merck
- 14,4740
- BRN
- 2213447
- Stability:
- Hygroscopic
- LogP
- 0.330
- CAS DataBase Reference
- 306-08-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzeneacetic acid, 4-hydroxy-3-methoxy-(306-08-1)
- EPA Substance Registry System
- Homovanillic acid (306-08-1)
MSDS
- Language:English Provider:3-Methoxy-4-hydroxyphenyl acetic acid
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
Homovanillic acid Usage And Synthesis
Description
Homovanillic acid (HVA) is a dopamine metabolite. It is formed via deamination of dopamine by monoamine oxidase (MAO) to produce 3,4-dihydroxyphenylacetic acid (DOPAC; ) followed by DOPAC metabolism by catechol-O-methyltransferase (COMT). HVA undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer that displays excitation/emission maxima of 312/420 nm, respectively. It has been used to quantify hydrogen peroxide production in macrophages and neutrophils.
Chemical Properties
white to beige crystalline powder
Uses
Fluorimetric reagent and major catecholamine metaboliteHomovanillic acid is used as a reagent in the determination of oxidative enzymes. It is associated with dopamine levels in the brain. Its presence supports a diagnosis of neuroblastoma and malignant pheochromocytoma.
Uses
A neuroendocrine tumor marker. Dihydroxyphenylacetic Acid (DOPAC) metabolite.
Definition
ChEBI: A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
Biological Activity
Fluorimetric reagent and major catecholamine metabolite. Used for fluorimetric determination of oxidative enzymes including glucose oxidase.
storage
+4°C
Homovanillic acid Preparation Products And Raw materials
Raw materials
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Homovanillic acid(306-08-1)Related Product Information
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- Stearic acid
- Vanillic acid
- DL-Mandelic acid
- 4-Hydroxyphenylacetic acid
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- Ethyl 2-(Chlorosulfonyl)acetate
- Ascoric Acid
- Acetic anhydride
- Testosterone phenylacetate
- 3,4,5-Trimethoxyphenylacetic acid
- HOMOVANILLIC ACID ETHYL ESTER,Homovanillic acid ethyl
- DL-4-HYDROXY-3-METHOXYMANDELIC ACID