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Homovanillic acid

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Homovanillic acid Basic information

Product Name:
Homovanillic acid
Synonyms:
  • 4-Hydroxy-3-methoxybenzeneacetic acid
  • 4-hydroxy-3-methoxy-benzeneaceticaci
  • 4-hydroxy-3-methoxy-Benzeneaceticacid
  • Acetic acid, (4-hydroxy-3-methoxyphenyl)-
  • Homovanilic acid
  • Homovanillinic acid
  • Vanilacetic acid
  • Vanillacetic Acid
CAS:
306-08-1
MF:
C9H10O4
MW:
182.17
EINECS:
206-176-7
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • Multisubstituted Benzene
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Pharmaceutical Intermediates
  • Aromatics
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
Mol File:
306-08-1.mol
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Homovanillic acid Chemical Properties

Melting point:
142-145 °C(lit.)
Boiling point:
235.56°C (rough estimate)
Density 
1.1634 (rough estimate)
refractive index 
1.4209 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
4.39±0.10(Predicted)
form 
Crystalline Powder
color 
White to beige
Water Solubility 
soluble
Merck 
14,4740
BRN 
2213447
Stability:
Hygroscopic
LogP
0.330
CAS DataBase Reference
306-08-1(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetic acid, 4-hydroxy-3-methoxy-(306-08-1)
EPA Substance Registry System
Homovanillic acid (306-08-1)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
10-23
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29189900

MSDS

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Homovanillic acid Usage And Synthesis

Description

Homovanillic acid (HVA) is a dopamine metabolite. It is formed via deamination of dopamine by monoamine oxidase (MAO) to produce 3,4-dihydroxyphenylacetic acid (DOPAC; ) followed by DOPAC metabolism by catechol-O-methyltransferase (COMT). HVA undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer that displays excitation/emission maxima of 312/420 nm, respectively. It has been used to quantify hydrogen peroxide production in macrophages and neutrophils.

Chemical Properties

white to beige crystalline powder

Uses

Fluorimetric reagent and major catecholamine metaboliteHomovanillic acid is used as a reagent in the determination of oxidative enzymes. It is associated with dopamine levels in the brain. Its presence supports a diagnosis of neuroblastoma and malignant pheochromocytoma.

Uses

A neuroendocrine tumor marker. Dihydroxyphenylacetic Acid (DOPAC) metabolite.

Definition

ChEBI: A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.

Biological Activity

Fluorimetric reagent and major catecholamine metabolite. Used for fluorimetric determination of oxidative enzymes including glucose oxidase.

storage

+4°C

Homovanillic acid Preparation Products And Raw materials

Raw materials

Homovanillic acidSupplier

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