QUINUCLIDINE Chemical Properties

Melting point:

157-160 °C (lit.)

Boiling point:

198.35°C (rough estimate)

Density 

0.8928 (rough estimate)

vapor pressure 

1.5 mm Hg ( 20 °C)

refractive index 

1.4500 (estimate)

solubility 

H2O: very slightly soluble

pka

10.87±0.33(Predicted)

form 

powder to crystal

color 

White to Light yellow

Water Solubility 

Soluble in alcohol, diethyl ether, water and organic solvents.

Sensitive 

Air Sensitive

Merck 

14,8081

BRN 

103111

InChIKey

SBYHFKPVCBCYGV-UHFFFAOYSA-N

CAS DataBase Reference

100-76-5(CAS DataBase Reference)

EPA Substance Registry System

1-Azabicyclo[2.2.2]octane (100-76-5)

Safety Information

Hazard Codes 

T

Risk Statements 

24/25-38-41

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

CL5594625

F 

2-10

TSCA 

Yes

HS Code 

2933.39.9200

HazardClass 

8

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich

QUINUCLIDINE Usage And Synthesis

Uses

Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. It is employed to prepare quinine and alkaloids. It finds application as a ligand, which is useful in the studies of OsO4-catalyzed dihydroxylation of olefins. It plays an important role in the formation of onium salts used testing of PAC-antagonist activity.

Definition

ChEBI: Quinuclidine is a saturated organic heterobicyclic parent and a member of quinuclidines.

Hazard

A poison by ingestion and skin contact. Low toxicity by inhalation. A moderate skin and severe eye irritant.

Purification Methods

Crystallise it from diethyl ether. The hydrochloride has m 364-365o(dec) (from EtOH or n-BuOH), and the picrate has m 225o (from aqueous EtOH). [Beilstein 20 H 144, 20 II 71, 20 III/IV 1966, 20/4 V 335.]

QUINUCLIDINE(100-76-5)Related Product Information

• 3-Aminoquinuclidine dihydrochloride
• A-(6-METHOXY-4-QUINOLYL)-5-VINYL-2-QUINUCLIDINE-METHANOL
• 3-Aminoquinuclidine
• Quinuclidine-4-carboxylic acid ethyl ester
• QUINUCLIDINE
• Cinchonidine
• QUININE FORMATE
• 3-Quinuclidinol hydrochloride
• CINCHONINE SULFATE
• QUINUCLIDINE HYDROCHLORIDE
• A-(6-METHOXY-4-QUINOLYL)-5-VINYL-2-QUINUCLIDINE-METHANOL VALERATE
• 3-Quinuclidinone hydrochloride
• 3-Quinuclidinol
• A-(6-METHOXY-4-QUINOLYL)-5-VINYL-2-QUINUCLIDINE-METHANOL SULFATE
• (S)-3-Aminoquinuclidine dihydrochloride
• 4-AMINO-N-1-AZABICYCLO[2.2.2]OCT-3-YL-5-CHLORO-2-METHOXYBENZAMIDE HYDROCHLORIDE
• (R)-3-Quinuclidinol hydrochloride
• (R)-3-Aminoquinuclidine dihydrochloride